Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy

Chikira, Makoto; Ng, Chew Hee; Palaniandavar, Mallayan

doi:10.3390/ijms160922754

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Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy

by

Makoto Chikira

^1,*,

Chew Hee Ng

² and

Mallayan Palaniandavar

³

¹

Department of Applied Chemistry, Chuo University, Kasuga, Bunkyou-ku, Tokyo 112-8551, Japan

²

Department of Pharmaceutical Chemistry, International Medical University, Kuala Lumpur 57000, Malaysia

³

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2015, 16(9), 22754-22780; https://doi.org/10.3390/ijms160922754

Submission received: 30 July 2015 / Revised: 30 August 2015 / Accepted: 9 September 2015 / Published: 21 September 2015

(This article belongs to the Special Issue Low Molecular Weight DNA and RNA Binding Agents)

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Abstract

The interaction of simple and ternary Cu(II) complexes of 1,10-phenanthrolines with DNA has been studied extensively because of their various interesting and important functions such as DNA cleavage activity, cytotoxicity towards cancer cells, and DNA based asymmetric catalysis. Such functions are closely related to the DNA binding modes of the complexes such as intercalation, groove binding, and electrostatic surface binding. A variety of spectroscopic methods have been used to study the DNA binding mode of the Cu(II) complexes. Of all these methods, DNA-fiber electron paramagnetic resonance (EPR) spectroscopy affords unique information on the DNA binding structures of the complexes. In this review we summarize the results of our DNA-fiber EPR studies on the DNA binding structure of the complexes and discuss them together with the data accumulated by using other measurements.

Keywords: electron paramagnetic resonance; DNA fiber; Cu(II) complexes; 1,10-phenanthrolines; DNA binding structures; DNA conformation

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MDPI and ACS Style

Chikira, M.; Ng, C.H.; Palaniandavar, M. Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy. Int. J. Mol. Sci. 2015, 16, 22754-22780. https://doi.org/10.3390/ijms160922754

AMA Style

Chikira M, Ng CH, Palaniandavar M. Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy. International Journal of Molecular Sciences. 2015; 16(9):22754-22780. https://doi.org/10.3390/ijms160922754

Chicago/Turabian Style

Chikira, Makoto, Chew Hee Ng, and Mallayan Palaniandavar. 2015. "Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy" International Journal of Molecular Sciences 16, no. 9: 22754-22780. https://doi.org/10.3390/ijms160922754

APA Style

Chikira, M., Ng, C. H., & Palaniandavar, M. (2015). Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy. International Journal of Molecular Sciences, 16(9), 22754-22780. https://doi.org/10.3390/ijms160922754

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Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy

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