Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies
Abstract
:1. Introduction
Name | Sequence | References |
---|---|---|
Poly-R peptides | Rx * | [19,20,2122] |
TAT (47–57) | YGRKKRRQRRR | [23] |
TAT (49–60) | RKKRRQRRRPPQ | [21] |
PTD4 | YARAAARQARA | [24] |
PTD5 | RRQRRTSKLMKRGG | [25] |
TP10 | AGYLLGKINLKALAALAKKIL | [26] |
M918 | MVTVLFRRLRIRRACGPPRVRV | [27] |
pAntp (43–58) [Penetratin] | RQIKIWFQNRRMKWKK | [21] |
KNO | KQINNWFINQRKRHWK | [28] |
Hph-1 | YARVRRRGPRR | [29] |
HIV-1 Rev (34–50) ANP (43–58) [Antennapedia] | TRQARRNRRRRWRERQR-GC RQIKIWFQNRRMKWKK-GC-CO | [30] |
POD | GGG [ARKKAAKA] 4 | [31] |
S413-PV | ALWKTLLKKVLKAPKKKRKV | [32] |
S41 | CVQWSLLRGYQPC | [33] |
pVEC | LLIILRRRIRKQAHAHSK | [34] |
2. CPPs-Modified Liposome
3. Combination of CPPs with Polymer
4. Combination of CPPs with Cationic Peptide
5. Binding of CPPs with the Viral Carrier
6. Calcium and CPPs
7. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
Abbreviation | Full Name |
Arg | Arginine |
Asp | Aspartic acid |
AVV | Adeno-associated virus |
BBB | Blood brain barrier |
C | Cysteine |
CAR | Coxsackievirus and adenovirus receptor |
CBA-DAH | Cystamine bisacrylamide-diaminohexane |
CNS | Central nervous system diseases |
CPP | Cell penetrating peptide |
dsRBD/DRBD | Doubled RNA binding domain |
G | Glycine |
Glu | Glutamic acid |
H | Histidine |
HA2 | hemagglutinin peptide |
HIV | Human immunodeficiency virus |
L | Leucine |
LMWP | Cell penetrating peptide of LMWP |
Lys/K | Lysine |
MAP | Model amphipathic peptide |
MNPs | Magnetic nanoparticles |
MPEG | Methoxy poly (ethylene glycol) |
P | Proline |
PCL | Poly(epsilon-caprolactone) |
PEG | Polyethylenglycol |
PLL | Poly-L-Lysine |
pLys | Polylysine |
PTD | Protein transduction domain |
PTD-DRBD | CPP of PTD modified dsRNA binding domain |
Q | Glutamine |
R | Arginine |
R8 | Polyarginine8 |
RNAi | RNA interference |
shRNA | Short hairpin RNA |
siRNA | Small interfering RNA |
TAT | Cell penetrating peptide of TAT |
TAT-PEG-MPLs | TAT-conjugated PEGlated Magnetic polymeric liposome |
TAT-U1A dsRBD | TAT conjugated with U1A dsRBD |
TP 10 | Transportan10 |
U1A | U1 small nuclear ribonucleoprotein A |
V | Valine |
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Li, H.; Tsui, T.Y.; Ma, W. Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies. Int. J. Mol. Sci. 2015, 16, 19518-19536. https://doi.org/10.3390/ijms160819518
Li H, Tsui TY, Ma W. Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies. International Journal of Molecular Sciences. 2015; 16(8):19518-19536. https://doi.org/10.3390/ijms160819518
Chicago/Turabian StyleLi, Hua, Tung Yu Tsui, and Wenxue Ma. 2015. "Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies" International Journal of Molecular Sciences 16, no. 8: 19518-19536. https://doi.org/10.3390/ijms160819518