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Int. J. Mol. Sci. 2015, 16(8), 19508-19517;

Terpenoids from the Octocoral Sinularia gaweli

1,2,†, 3,†, 4,5, 6, 7, 8, 3,9,10,11,* and 1,2,3,6,11,*
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Vassilios Roussis and Efstathia Ioannou
Received: 8 July 2015 / Revised: 6 August 2015 / Accepted: 10 August 2015 / Published: 18 August 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
PDF [1135 KB, uploaded 18 August 2015]


Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 24 are new isolates. The structures of new terpenoids 24 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells. View Full-Text
Keywords: Sinularia gaweli; eudesmane; cembrane; octocoral; iNOS Sinularia gaweli; eudesmane; cembrane; octocoral; iNOS

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Lin, W.-J.; Wu, T.-Y.; Su, T.-R.; Wen, Z.-H.; Chen, J.-J.; Fang, L.-S.; Wu, Y.-C.; Sung, P.-J. Terpenoids from the Octocoral Sinularia gaweli. Int. J. Mol. Sci. 2015, 16, 19508-19517.

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