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Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

1
Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
2
Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
3
Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yuping Bao
Int. J. Mol. Sci. 2015, 16(8), 18283-18292; https://doi.org/10.3390/ijms160818283
Received: 29 June 2015 / Revised: 21 July 2015 / Accepted: 29 July 2015 / Published: 6 August 2015
(This article belongs to the Special Issue Developmental and Reproductive Toxicity of Iron Oxide Nanoparticles)
Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm2 power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity. View Full-Text
Keywords: FeCo nanocubes; polydopamine; microwave radiation; nanomedicine FeCo nanocubes; polydopamine; microwave radiation; nanomedicine
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MDPI and ACS Style

Julfakyan, K.; Fatieiev, Y.; Alsaiari, S.; Deng, L.; Ezzeddine, A.; Zhang, D.; Rotello, V.M.; Khashab, N.M. Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes. Int. J. Mol. Sci. 2015, 16, 18283-18292. https://doi.org/10.3390/ijms160818283

AMA Style

Julfakyan K, Fatieiev Y, Alsaiari S, Deng L, Ezzeddine A, Zhang D, Rotello VM, Khashab NM. Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes. International Journal of Molecular Sciences. 2015; 16(8):18283-18292. https://doi.org/10.3390/ijms160818283

Chicago/Turabian Style

Julfakyan, Khachatur, Yevhen Fatieiev, Shahad Alsaiari, Lin Deng, Alaa Ezzeddine, Dingyuan Zhang, Vincent M. Rotello, and Niveen M. Khashab 2015. "Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes" International Journal of Molecular Sciences 16, no. 8: 18283-18292. https://doi.org/10.3390/ijms160818283

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