Next Article in Journal
Human Adipose-Derived Mesenchymal Progenitor Cells Engraft into Rabbit Articular Cartilage
Previous Article in Journal
1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation
Open AccessArticle

The Cross-Bridge of Skeletal Muscle Is Not Synchronized Either by Length or Force Step

Department of Scienze Biomediche e Chirurgiche Specialistiche, Ferrara University, Via Borsari 46, 44121 Ferrara, Italy
Academic Editor: Charles J. Malemud
Int. J. Mol. Sci. 2015, 16(6), 12064-12075; https://doi.org/10.3390/ijms160612064
Received: 30 January 2015 / Revised: 13 May 2015 / Accepted: 22 May 2015 / Published: 27 May 2015
(This article belongs to the Section Biochemistry)
Force and length steps, applied to a muscle fiber in the isometric state, are believed to synchronize attached cross-bridges. This alleged synchronization facilitates the interpretation of the experiments. A rapid force step elicits an elastic response of the attached cross-bridges, followed by an isotonic phase. The decay of this second isotonic phase is of the first order. This excludes that the attached cross-bridges may decay all at the same time. The change of the X-ray interference distance during the second phase measures the stroke size only in the unrealistic case that the cross-bridges are and remain all attached. A rapid force step does not synchronize attached cross-bridges. The change of X-ray interference during the second phase does not measure the stroke size. These conclusions significantly change the picture of the mechanism of skeletal muscle contraction. View Full-Text
Keywords: skeletal muscle contraction; cross-bridges synchronization; interference distance; power stroke skeletal muscle contraction; cross-bridges synchronization; interference distance; power stroke
Show Figures

Figure 1

MDPI and ACS Style

Grazi, E. The Cross-Bridge of Skeletal Muscle Is Not Synchronized Either by Length or Force Step. Int. J. Mol. Sci. 2015, 16, 12064-12075.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop