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Int. J. Mol. Sci. 2015, 16(5), 10888-10906;

Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone

Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, Second Military Medical University, Shanghai 200438, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 27 March 2015 / Revised: 10 April 2015 / Accepted: 22 April 2015 / Published: 13 May 2015
(This article belongs to the Section Biochemistry)
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Costunolide (CE) and dehydrocostuslactone (DE) are derived from many species of medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. They have been reported for their wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal, antioxidant, antidiabetic, antiulcer, and anthelmintic activities. In recent years, they have caused extensive interest in researchers due to their potential anti-cancer activities for various types of cancer, and their anti-cancer mechanisms, including causing cell cycle arrest, inducing apoptosis and differentiation, promoting the aggregation of microtubule protein, inhibiting the activity of telomerase, inhibiting metastasis and invasion, reversing multidrug resistance, restraining angiogenesis has been studied. This review will summarize anti-cancer activities and associated molecular mechanisms of these two compounds for the purpose of promoting their research and application. View Full-Text
Keywords: costunolide; dehydrocostuslactone; cancer treatment; molecular mechanism costunolide; dehydrocostuslactone; cancer treatment; molecular mechanism

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Lin, X.; Peng, Z.; Su, C. Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone. Int. J. Mol. Sci. 2015, 16, 10888-10906.

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