Next Article in Journal
Calculated Third Order Rate Constants for Interpreting the Mechanisms of Hydrolyses of Chloroformates, Carboxylic Acid Halides, Sulfonyl Chlorides and Phosphorochloridates
Next Article in Special Issue
The Effect of Electrospun Gelatin Fibers Alignment on Schwann Cell and Axon Behavior and Organization in the Perspective of Artificial Nerve Design
Previous Article in Journal
Removal of Toxic Mercury from Petroleum Oil by Newly Synthesized Molecularly-Imprinted Polymer
Previous Article in Special Issue
MicroRNAs Regulate Bone Development and Regeneration
 
 
Review

Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

1
Division of Neurology, Department of clinical Neuroscience, Geneva University Hospitals, 1205 Geneva, Switzerland
2
Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
3
Department of Oncology, Geneva University Hospital and Medical School, 1205 Geneva, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Aaron Tan
Int. J. Mol. Sci. 2015, 16(5), 10578-10600; https://doi.org/10.3390/ijms160510578
Received: 11 March 2015 / Revised: 28 April 2015 / Accepted: 30 April 2015 / Published: 8 May 2015
(This article belongs to the Special Issue Artificial Organs)
Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines. View Full-Text
Keywords: cellular implants; genetic engineering; encapsulation; passive immunization; recombinant antibodies; Alzheimer’s disease; cytokine; adjuvant; cancer vaccine cellular implants; genetic engineering; encapsulation; passive immunization; recombinant antibodies; Alzheimer’s disease; cytokine; adjuvant; cancer vaccine
Show Figures

Figure 1

MDPI and ACS Style

Lathuilière, A.; Mach, N.; Schneider, B.L. Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System. Int. J. Mol. Sci. 2015, 16, 10578-10600. https://doi.org/10.3390/ijms160510578

AMA Style

Lathuilière A, Mach N, Schneider BL. Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System. International Journal of Molecular Sciences. 2015; 16(5):10578-10600. https://doi.org/10.3390/ijms160510578

Chicago/Turabian Style

Lathuilière, Aurélien, Nicolas Mach, and Bernard L. Schneider. 2015. "Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System" International Journal of Molecular Sciences 16, no. 5: 10578-10600. https://doi.org/10.3390/ijms160510578

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop