Dermal Contributions to Human Interfollicular Epidermal Architecture and Self-Renewal
by
Kynan T. Lawlor and Pritinder Kaur *
Kynan T. Lawlor and Pritinder Kaur *
Hudson Institute of Medical Research, Clayton, VIC 3168, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Miroslav Blumenberg
Int. J. Mol. Sci. 2015, 16(12), 28098-28107; https://doi.org/10.3390/ijms161226078
Received: 16 October 2015 / Revised: 10 November 2015 / Accepted: 17 November 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells 2015)
The human interfollicular epidermis is renewed throughout life by populations of proliferating basal keratinocytes. Though interfollicular keratinocyte stem cells have been identified, it is not known how self-renewal in this compartment is spatially organized. At the epidermal-dermal junction, keratinocytes sit atop a heterogeneous mix of dermal cells that may regulate keratinocyte self-renewal by influencing local tissue architecture and signalling microenvironments. Focusing on the rete ridges and complementary dermal papillae in human skin, we review the identity and organisation of abundant dermal cells types and present evidence for interactions between the dermal microenvironment and the interfollicular keratinocytes.
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Keywords:
keratinocyte; epidermis; self-renewal; dermis; stem cell; microenvironment; vasculature; pericyte; endothelial; fibroblast
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MDPI and ACS Style
Lawlor, K.T.; Kaur, P. Dermal Contributions to Human Interfollicular Epidermal Architecture and Self-Renewal. Int. J. Mol. Sci. 2015, 16, 28098-28107.
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