Photodynamic Therapy (PDT) with Chemotherapy for Advanced Lung Cancer with Airway Stenosis
Abstract
:1. Introduction
2. Results and Discussion
2.1. Patient and Tumor Characteristics
2.2. Treatment Results
Case | Age | Patho | c-Stage | Chemotherapy | Location | Probe | before PDT S.R. | 1W after PDT S.R. | 1M after PDT S.R. | Survival (Day) | Outcome | CTCAE v4.0 (Grade) | KS (before) | KS (after) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 77 | Sq | IIA | CBDCA + TS-1 | LU (B1 + 2) | F and R | 45% | 15% | 15% | 224 | Death | 1 | 90 | 100 |
2 | 74 | LCNEC | IIIB | NDP + DOC | R Int | F and R | 100% | 60% | 15% | 160 | Death | 1 | 20 | 100 |
3 | 74 | Sq | IIB | CBDCA + TS-1 CBDCA + VNR | R Int | F and R | 60% | 15% | 30% | 638 | Death | 3 | 90 | 90 |
4 | 69 | Ad | IV | TS-1 | RM | F and R | 30% | 15% | 30% | 61 | Death | 1 | 20 | 90 |
5 | 75 | Sq | IV | CDDP + DOC | RM | F and R | 30% | 15% | 45% | 93 | Death | 3 | 80 | 90 |
6 | 74 | Giant | IV | CDDP + DOC | RL | F and R | 100% | 99% | 60% | 425 | Death | 1 | 70 | 100 |
7 | 72 | Sq | IV | CDDP + DOC | Carina | F | R 30% L 60% | R 15% L 15% | R 15% L 15% | 196 | Death | 3 | 90 | 100 |
8 | 58 | Sq | IIIB | CBDCA + TS-1 | RU (B2,3) | F and R | 45% | 30% | 15% | 614 | Alive | 1 | 90 | 100 |
9 | 77 | Sq | IIIA | NDP + DOC | RU | F | 99% | 15% | 15% | 38 | Death | 4 | 90 | 100 |
10 | 78 | ad | IIIA | CBDCA + PEM + Bev CBDCA + PTX + Bev | RU(B3) | F and R | 60% | 30% | 60% | 159 | Death | 1 | 100 | 100 |
11 | 80 | ad | IV | CBDCA + PEM + Bev | RU | F and R | 99% | 15% | 30% | 89 | Alive | 1 | 80 | 90 |
12 | 70 | sq | IIIB | CBDCA + nab-PTX CBDCA + TS-1 | R Int | F and R | 100% | 30% | 15% | 195 | Alive | 1 | 80 | 100 |
2.3. Tumor Responses on Computed Tomography
2.4. Discussion
3. Experimental Section
3.1. Patients
3.2. Photosensitizer and Laser Unit
3.3. Treatment Protocol
3.4. Evaluation of Effectiveness
3.5. Statistical Analyses
4. Conclusions
Author Contributions
Conflicts of Interest
References
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Kimura, M.; Miyajima, K.; Kojika, M.; Kono, T.; Kato, H. Photodynamic Therapy (PDT) with Chemotherapy for Advanced Lung Cancer with Airway Stenosis. Int. J. Mol. Sci. 2015, 16, 25466-25475. https://doi.org/10.3390/ijms161025466
Kimura M, Miyajima K, Kojika M, Kono T, Kato H. Photodynamic Therapy (PDT) with Chemotherapy for Advanced Lung Cancer with Airway Stenosis. International Journal of Molecular Sciences. 2015; 16(10):25466-25475. https://doi.org/10.3390/ijms161025466
Chicago/Turabian StyleKimura, Masakazu, Kuniharu Miyajima, Masakazu Kojika, Takafumi Kono, and Harubumi Kato. 2015. "Photodynamic Therapy (PDT) with Chemotherapy for Advanced Lung Cancer with Airway Stenosis" International Journal of Molecular Sciences 16, no. 10: 25466-25475. https://doi.org/10.3390/ijms161025466