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Int. J. Mol. Sci. 2015, 16(1), 321-349;

tRNAs as Antibiotic Targets

Department of Cell Biology and Physiology, the University of North Carolina at Chapel Hill, 536 Taylor Hall, 109 Mason Farm Road, Chapel Hill, NC 27599-7545, USA
Author to whom correspondence should be addressed.
Academic Editor: Michael Ibba
Received: 25 November 2014 / Accepted: 19 December 2014 / Published: 25 December 2014
(This article belongs to the Special Issue Functions of Transfer RNAs)
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Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial “stringent response” mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed. View Full-Text
Keywords: tRNA; protein translation; antibiotics; stringent response; biogenesis tRNA; protein translation; antibiotics; stringent response; biogenesis

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Chopra, S.; Reader, J. tRNAs as Antibiotic Targets. Int. J. Mol. Sci. 2015, 16, 321-349.

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