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Mesenchymal Stem Cell-Derived Microparticles: A Promising Therapeutic Strategy

Division of Stem Cell Regulation and Application, College of Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
Department of Biochemistry & Molecular Biology, Libin Cardiovascular Institute of Alberta, Smooth Muscle Research Group, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB T2N4N1, Canada
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(8), 14348-14363;
Received: 18 June 2014 / Revised: 25 July 2014 / Accepted: 4 August 2014 / Published: 18 August 2014
(This article belongs to the Section Biochemistry)
PDF [4023 KB, uploaded 19 August 2014]


Mesenchymal stem cells (MSCs) are multipotent stem cells that give rise to various cell types of the mesodermal germ layer. Because of their unique ability to home in on injured and cancerous tissues, MSCs are of great potential in regenerative medicine. MSCs also contribute to reparative processes in different pathological conditions, including cardiovascular diseases and cancer. However, many studies have shown that only a small proportion of transplanted MSCs can actually survive and be incorporated into host tissues. The effects of MSCs cannot be fully explained by their number. Recent discoveries suggest that microparticles (MPs) derived from MSCs may be important for the physiological functions of their parent. Though the physiological role of MSC-MPs is currently not well understood, inspiring results indicate that, in tissue repair and anti-cancer therapy, MSC-MPs have similar pro-regenerative and protective properties as their cellular counterparts. Thus, MSC-MPs represent a promising approach that may overcome the obstacles and risks associated with the use of native or engineered MSCs. View Full-Text
Keywords: mesenchymal stem cells; microparticles; intercellular communication; clinical therapy mesenchymal stem cells; microparticles; intercellular communication; clinical therapy

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tan, X.; Gong, Y.-Z.; Wu, P.; Liao, D.-F.; Zheng, X.-L. Mesenchymal Stem Cell-Derived Microparticles: A Promising Therapeutic Strategy. Int. J. Mol. Sci. 2014, 15, 14348-14363.

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