Next Article in Journal
Antibody-Conjugated Paramagnetic Nanobeads: Kinetics of Bead-Cell Binding
Next Article in Special Issue
Qualitative Analysis of the Helical Electronic Energy of Inherently Chiral Calix[4]arenes: An Approach to Effectively Assign Their Absolute Configuration
Previous Article in Journal
Biological Evaluation and 3D-QSAR Studies of Curcumin Analogues as Aldehyde Dehydrogenase 1 Inhibitors
Previous Article in Special Issue
Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides
Open AccessCommunication

Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues

1
Department of Phytochemistry, School of Pharmacy, School of Pharmacy, Second Military Medical University, 325 Guo He Road, Shanghai 200433, China
2
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(5), 8808-8820; https://doi.org/10.3390/ijms15058808
Received: 1 March 2014 / Revised: 31 March 2014 / Accepted: 17 April 2014 / Published: 16 May 2014
(This article belongs to the Special Issue Molecular Science for Drug Development and Biomedicine)
A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification. View Full-Text
Keywords: anti-inflammatory; caffeic acid amides; synthesis; pharmacophore; target predication anti-inflammatory; caffeic acid amides; synthesis; pharmacophore; target predication
MDPI and ACS Style

Liu, Z.; Fu, J.; Shan, L.; Sun, Q.; Zhang, W. Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues. Int. J. Mol. Sci. 2014, 15, 8808-8820.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop