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Open AccessReview

Biomarkers in Alzheimer’s Disease Analysis by Mass Spectrometry-Based Proteomics

by Yahui Liu, Hong Qing and Yulin Deng *
School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(5), 7865-7882; https://doi.org/10.3390/ijms15057865
Received: 19 March 2014 / Revised: 3 April 2014 / Accepted: 9 April 2014 / Published: 6 May 2014
(This article belongs to the Collection Advances in Proteomic Research)
Alzheimer’s disease (AD) is a common chronic and destructive disease. The early diagnosis of AD is difficult, thus the need for clinically applicable biomarkers development is growing rapidly. There are many methods to biomarker discovery and identification. In this review, we aim to summarize Mass spectrometry (MS)-based proteomics studies on AD and discuss thoroughly the methods to identify candidate biomarkers in cerebrospinal fluid (CSF) and blood. This review will also discuss the potential research areas on biomarkers. View Full-Text
Keywords: biomarker; Alzheimer’s disease; mass spectrometry; proteomics biomarker; Alzheimer’s disease; mass spectrometry; proteomics
MDPI and ACS Style

Liu, Y.; Qing, H.; Deng, Y. Biomarkers in Alzheimer’s Disease Analysis by Mass Spectrometry-Based Proteomics. Int. J. Mol. Sci. 2014, 15, 7865-7882.

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