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Open AccessArticle

Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics

1
Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China
2
Department of Physical Education of Nan Yang Institute of Technology, Nanyang 473000, China
3
Center for Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(4), 5304-5322; https://doi.org/10.3390/ijms15045304
Received: 14 November 2013 / Revised: 7 February 2014 / Accepted: 14 March 2014 / Published: 26 March 2014
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
Aerobic interval training (AIT) can favorably affect cardiovascular diseases. However, the effects of AIT on post-myocardial infarction (MI)—associated mitochondrial dysfunctions remain unclear. In this study, we investigated the protective effects of AIT on myocardial mitochondria in post-MI rats by focusing on mitochondrial dynamics (fusion and fission). Mitochondrial respiratory functions (as measured by the respiratory control ratio (RCR) and the ratio of ADP to oxygen consumption (P/O)); complex activities; dynamic proteins (mitofusin (mfn) 1/2, type 1 optic atrophy (OPA1) and dynamin-related protein1 (DRP1)); nuclear peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α); and the oxidative signaling of extracellular signal-regulated kinase (ERK) 1/2, c-Jun NH2-terminal protein kinase (JNK) and P53 were observed. Post-MI rats exhibited mitochondrial dysfunction and adverse mitochondrial network dynamics (reduced fusion and increased fission), which was associated with activated ERK1/2-JNK-P53 signaling and decreased nuclear PGC-1α. After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1α and inactivation of the ERK1/2-JNK-P53 signaling were observed. These data demonstrate that AIT may restore the post-MI mitochondrial function by inhibiting dynamics pathological remodeling, which may be associated with inactivation of ERK1/2-JNK-P53 signaling and increase in nuclear PGC-1α expression. View Full-Text
Keywords: myocardial infarction; mitochondrial dysfunction; fusion; fission; mitochondrial dynamics; aerobic interval training myocardial infarction; mitochondrial dysfunction; fusion; fission; mitochondrial dynamics; aerobic interval training
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MDPI and ACS Style

Jiang, H.-K.; Wang, Y.-H.; Sun, L.; He, X.; Zhao, M.; Feng, Z.-H.; Yu, X.-J.; Zang, W.-J. Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics. Int. J. Mol. Sci. 2014, 15, 5304-5322. https://doi.org/10.3390/ijms15045304

AMA Style

Jiang H-K, Wang Y-H, Sun L, He X, Zhao M, Feng Z-H, Yu X-J, Zang W-J. Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics. International Journal of Molecular Sciences. 2014; 15(4):5304-5322. https://doi.org/10.3390/ijms15045304

Chicago/Turabian Style

Jiang, Hong-Ke; Wang, You-Hua; Sun, Lei; He, Xi; Zhao, Mei; Feng, Zhi-Hui; Yu, Xiao-Jiang; Zang, Wei-Jin. 2014. "Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics" Int. J. Mol. Sci. 15, no. 4: 5304-5322. https://doi.org/10.3390/ijms15045304

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