Next Article in Journal
Investigation into Variation of Endogenous Metabolites in Bone Marrow Cells and Plasma in C3H/He Mice Exposed to Benzene
Next Article in Special Issue
Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics
Previous Article in Journal
P-Glycoprotein and Drug Resistance in Systemic Autoimmune Diseases
Previous Article in Special Issue
Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(3), 4977-4993;

The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia

Translational Research Laboratory, Department of Research and Statistics, IRCCS Arcispedale S.Maria Nuova, 42123 Reggio Emilia, Italy
Author to whom correspondence should be addressed.
Received: 3 February 2014 / Revised: 27 February 2014 / Accepted: 12 March 2014 / Published: 20 March 2014
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
Full-Text   |   PDF [453 KB, uploaded 19 June 2014]   |  


Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors. View Full-Text
Keywords: resveratrol; non-Hodgkin lymphoma; apoptosis resveratrol; non-Hodgkin lymphoma; apoptosis

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Frazzi, R.; Tigano, M. The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia. Int. J. Mol. Sci. 2014, 15, 4977-4993.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top