Apoptosis Signal Regulating Kinase 1 (ASK1):  Potential as a Therapeutic Target for Alzheimer’s Disease

Song, Juhyun; Park, Kyung Ah; Lee, Won Taek; Lee, Jong Eun

doi:10.3390/ijms15022119

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Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

by

Juhyun Song

¹,

Kyung Ah Park

¹,

Won Taek Lee

¹ and

Jong Eun Lee

^1,2,*

¹

Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea

²

BK21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Korea

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2014, 15(2), 2119-2129; https://doi.org/10.3390/ijms15022119

Submission received: 27 November 2013 / Revised: 20 January 2014 / Accepted: 21 January 2014 / Published: 29 January 2014

(This article belongs to the Special Issue Neuroprotective Strategies 2014)

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia, characterized by a decline in memory and cognitive function. Clinical manifestations of AD are closely associated with the formation of senile plaques and neurofibrillary tangles, neuronal loss and cognitive decline. Apoptosis signal regulating kinase 1 (ASK1) is a mediator of the MAPK pathway, which regulates various cellular responses such as apoptosis, cell survival, and differentiation. Accumulating evidence indicates that ASK1 plays a key role in the pathogenesis of neurodegenerative disorders such as Huntington’s disease and AD. Of particular interest, ASK1 is associated with many signaling pathways, which include endoplasmic reticulum (ER) stress-mediated apoptosis, Aβ-induced neurotoxicity, tau protein phosphorylation, and insulin signal transduction. Here, we review experimental evidence that links ASK1 signaling and AD pathogenesis and propose that ASK1 might be a new point of therapeutic intervention to prevent or treat AD.

Keywords: apoptosis signal regulating kinase 1 (ASK1); Alzheimer’s disease (AD); oxidative stress; endoplasmic reticulum (ER) stress; Aβ neurotoxicity; tau protein phosphorylation; insulin signal transduction

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MDPI and ACS Style

Song, J.; Park, K.A.; Lee, W.T.; Lee, J.E. Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease. Int. J. Mol. Sci. 2014, 15, 2119-2129. https://doi.org/10.3390/ijms15022119

AMA Style

Song J, Park KA, Lee WT, Lee JE. Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease. International Journal of Molecular Sciences. 2014; 15(2):2119-2129. https://doi.org/10.3390/ijms15022119

Chicago/Turabian Style

Song, Juhyun, Kyung Ah Park, Won Taek Lee, and Jong Eun Lee. 2014. "Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease" International Journal of Molecular Sciences 15, no. 2: 2119-2129. https://doi.org/10.3390/ijms15022119

APA Style

Song, J., Park, K. A., Lee, W. T., & Lee, J. E. (2014). Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease. International Journal of Molecular Sciences, 15(2), 2119-2129. https://doi.org/10.3390/ijms15022119

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Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

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