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Int. J. Mol. Sci. 2014, 15(12), 23640-23657;

Emerging Regulation and Function of Betatrophin

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
First Cardiovascular Division, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Author to whom correspondence should be addressed.
Received: 11 July 2014 / Revised: 30 September 2014 / Accepted: 12 December 2014 / Published: 18 December 2014
(This article belongs to the Section Biochemistry)
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Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. In murine models, serum triglyceride levels as well as pancreatic cell proliferation are potently enhanced by betatrophin. Intriguingly, conflicting phenomena have also been reported that betatrophin suppresses hepatic triglyceride levels, suggesting that betatrophin function is mediated by complex regulatory processes. However, its precise physiological role remains unclear at present. In this review, we have summarized the current findings on betatrophin and their implications. View Full-Text
Keywords: betatrophin; C19orf80; chromosome 19 open reading frame 80; RIFL; lipasin; ANGPTL8; TD26; thyroid hormone; irisin; insulin and lipid betatrophin; C19orf80; chromosome 19 open reading frame 80; RIFL; lipasin; ANGPTL8; TD26; thyroid hormone; irisin; insulin and lipid

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Tseng, Y.-H.; Yeh, Y.-H.; Chen, W.-J.; Lin, K.-H. Emerging Regulation and Function of Betatrophin. Int. J. Mol. Sci. 2014, 15, 23640-23657.

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