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LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases

by and *
Division of Nephrology, Department of Medicine, College of Medicine, Penn State University, 500 University Drive, Hershey, PA 17033, USA
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(12), 22887-22901; https://doi.org/10.3390/ijms151222887
Received: 24 September 2014 / Revised: 6 November 2014 / Accepted: 4 December 2014 / Published: 10 December 2014
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells 2014)
Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases. In addition to its function as a scavenger receptor for various ligands, LRP-1 has been shown to transduce multiple intracellular signal pathways including mitogen-activated protein kinase (MAPK), Akt, Rho, and the integrin signaling. LRP-1 signaling plays an important role in the regulation of diverse cellular process, such as cell proliferation, survival, motility, differentiation, and transdifferentiation, and thus participates in the pathogenesis of organ dysfunction and injury. In this review, we focus on the current understanding of LRP-1 signaling and its roles in the development and progression of kidney disease. The role and signaling of LRP-1 in the nervous and cardiovascular systems, as well as in carcinogenesis, are also briefly discussed. View Full-Text
Keywords: LRP-1; signaling; tPA; integrin; tyrosine phosphorylation; pathophysiology LRP-1; signaling; tPA; integrin; tyrosine phosphorylation; pathophysiology
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Lin, L.; Hu, K. LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases. Int. J. Mol. Sci. 2014, 15, 22887-22901.

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