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Int. J. Mol. Sci. 2014, 15(11), 20607-20637;

Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

School of Pharmacy, Griffith University, Queensland 4222, Australia
Griffith Health Institute, Griffith University, Queensland 4222, Australia
Department of Biomedical Science, Bond University, Queensland 4226, Australia
School of Medical Sciences, Griffith University, Queensland, 4222, Australia
Author to whom correspondence should be addressed.
Received: 16 September 2014 / Revised: 23 October 2014 / Accepted: 30 October 2014 / Published: 10 November 2014
(This article belongs to the Special Issue Molecular Research in Neurotoxicology)
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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary and secondary prevention against cardiovascular disease and stroke. Statins’ effects on the central nervous system (CNS), particularly on cognition and neurological disorders such as stroke and multiple sclerosis, have received increasing attention in recent years, both within the scientific community and in the media. Current understanding of statins’ effects is limited by a lack of mechanism-based studies, as well as the assumption that all statins have the same pharmacological effect in the central nervous system. This review aims to provide an updated discussion on the molecular mechanisms contributing to statins’ possible effects on cognitive function, neurodegenerative disease, and various neurological disorders such as stroke, epilepsy, depression and CNS cancers. Additionally, the pharmacokinetic differences between statins and how these may result in statin-specific neurological effects are also discussed. View Full-Text
Keywords: statin; cognition; central nervous system (CNS); neurotoxicity; neuroprotection statin; cognition; central nervous system (CNS); neurotoxicity; neuroprotection

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McFarland, A.J.; Anoopkumar-Dukie, S.; Arora, D.S.; Grant, G.D.; McDermott, C.M.; Perkins, A.V.; Davey, A.K. Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System. Int. J. Mol. Sci. 2014, 15, 20607-20637.

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