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Open AccessArticle

Rosmarinus Officinalis Leaves as a Natural Source of Bioactive Compounds

Department of Analytical Chemistry, University of Granada, c/Fuentenueva s/n, 18071 Granada, Spain
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento s/n., Edificio BioRegion, 18016 Granada, Spain
Faculty of Technology, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(11), 20585-20606;
Received: 22 July 2014 / Revised: 23 October 2014 / Accepted: 31 October 2014 / Published: 10 November 2014
(This article belongs to the Special Issue Bioactive Phenolics and Polyphenols)
In an extensive search for bioactive compounds from plant sources, the composition of different extracts of rosemary leaves collected from different geographical zones of Serbia was studied. The qualitative and quantitative characterization of 20 rosemary (Rosmarinus officinalis) samples, obtained by microwave-assisted extraction (MAE), was determined by high performance liquid chromatography coupled to electrospray quadrupole-time of flight mass spectrometry (HPLC–ESI-QTOF-MS). The high mass accuracy and true isotopic pattern in both MS and MS/MS spectra provided by the QTOF-MS analyzer enabled the characterization of a wide range of phenolic compounds in the extracts, including flavonoids, phenolic diterpenes and abietan-type triterpenoids, among others. According to the data compiled, rosemary samples from Sokobanja presented the highest levels in flavonoids and other compounds such as carnosol, rosmaridiphenol, rosmadial, rosmarinic acid, and carnosic acid. On the other hand, higher contents in triterpenes were found in the extracts of rosemary from Gložan (Vojvodina). View Full-Text
Keywords: Rosmarinus officinalis; phenolic compounds; HPLC; QTOF-MS Rosmarinus officinalis; phenolic compounds; HPLC; QTOF-MS
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Borrás-Linares, I.; Stojanović, Z.; Quirantes-Piné, R.; Arráez-Román, D.; Švarc-Gajić, J.; Fernández-Gutiérrez, A.; Segura-Carretero, A. Rosmarinus Officinalis Leaves as a Natural Source of Bioactive Compounds. Int. J. Mol. Sci. 2014, 15, 20585-20606.

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