Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population
Abstract
:1. Introduction
2. Results and Discussion
2.1. The Characteristics of Patients and Controls
Variables | Cases (n = 367) | Controls (n = 420) | p |
---|---|---|---|
n (%) | n (%) | ||
Age (years) | |||
Mean ± SD | 65.9 ± 11.8 | 65.0 ± 11.7 | 0.305 |
≤65 | 168 (45.78) | 197 (46.90) | 0.752 |
>65 | 199 (54.22) | 223 (53.10) | |
Sex | |||
Female | 69 (18.80) | 88 (20.95) | 0.451 |
Male | 298 (82.20) | 332 (79.05) | |
Smoking Status | |||
Never smoker | 149 (40.60) | 252 (60.00) | <0.001 |
Former smoker | 115 (31.34) | 67 (15.95) | |
Current smoker | 103 (28.06) | 101 (24.05) | |
Tumor Grade | |||
Low grade | 135 (36.78) | – | – |
High grade | 232 (63.22) | – | – |
Tumor Stage | |||
NMIBC | 276 (75.20) | – | – |
MIBC | 91 (24.80) | – | – |
2.2. Association between rs11892031 and Bladder Cancer Susceptibility
Genotypes | Cases (n = 367) | Controls (n = 420) | p | OR (95% CI) * |
---|---|---|---|---|
n (%) | n (%) | |||
AA | 363 (98.91) | 401 (95.48) | – | 1.00 |
AC | 4 (1.09) | 19 (4.52) | 0.019 | 0.27(0.09–0.81) |
CC | – | – | – | – |
A allele | 0.995 | 0.977 | – | 1.00 |
C allele | 0.005 | 0.023 | 0.020 | 0.28(0.09–0.82) |
Variables | rs11892031 Genotype, n (%) | p | OR (95% CI) * | |
---|---|---|---|---|
AA | AC | AC versus AA | ||
Controls (n = 420) | 401 (95.48) | 19 (4.52) | – | 1.00 |
Cases (n = 367) | ||||
Total | 363 (98.91) | 4 (1.09) | 0.019 | 0.27 (0.09–0.81) |
Tumor Grade | ||||
Low grade | 133 (98.51) | 2 (1.49) | 0.218 | 0.39 (0.09–1.73) |
High grade | 230 (99.14) | 2 (0.86) | 0.034 | 0.20 (0.05–0.88) |
Tumor Stage | ||||
NMIBC | 273 (98.91) | 3 (1.09) | 0.038 | 0.27 (0.08–0.93) |
MIBC | 90 (98.90) | 1 (1.10) | 0.195 | 0.26 (0.03–1.99) |
2.3. Association between rs401681 and Bladder Cancer Susceptibility
Genotypes | Cases (n = 367) | Controls (n = 420) | p | OR (95% CI) * |
---|---|---|---|---|
n (%) | n (%) | |||
TT | 28 (7.63) | 53 (12.62) | – | 1.00 |
CT | 166 (45.23) | 187 (44.52) | 0.044 | 1.69 (1.01–2.81) |
CC | 173 (47.14) | 180 (42.86) | 0.015 | 1.90 (1.13–3.18) |
CT/CC | 339 (92.37) | 367 (87.38) | 0.020 | 1.79 (1.10–2.91) |
T allele | 0.302 | 0.349 | – | 1.00 |
C allele | 0.698 | 0.651 | 0.035 | 1.26 (1.02–1.57) |
Variables | rs401681 Genotype, n (%) | p | OR (95% CI) * | |
---|---|---|---|---|
TT | CT/CC | CT/CC versus TT | ||
Controls (n = 420) | 53 (12.62) | 367 (87.38) | – | 1.00 |
Cases (n = 367) | ||||
Total | 28 (7.63) | 339 (92.37) | 0.020 | 1.79 (1.10–2.91) |
Tumor grade | ||||
Low grade | 14 (10.37) | 121 (89.63) | 0.503 | 1.24 (0.66–2.31) |
High grade | 14 (6.03) | 218 (93.97) | 0.011 | 2.24 (1.21–4.14) |
Tumor stage | ||||
NMIBC | 23 (8.33) | 253 (91.67) | 0.078 | 1.59 (0.95–2.66) |
MIBC | 4 (4.40) | 87 (95.60) | 0.029 | 3.21 (1.13–9.16) |
2.4. Discussion
3. Experimental Section
3.1. Patients and Controls
3.2. Classification of Grade and Stage for Tumor
3.3. Genotyping
3.4. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Zhang, Y.; Sun, Y.; Chen, T.; Hu, H.; Xie, W.; Qiao, Z.; Ding, N.; Xie, L.; Li, S.; Wang, W.; et al. Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population. Int. J. Mol. Sci. 2014, 15, 19330-19341. https://doi.org/10.3390/ijms151119330
Zhang Y, Sun Y, Chen T, Hu H, Xie W, Qiao Z, Ding N, Xie L, Li S, Wang W, et al. Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population. International Journal of Molecular Sciences. 2014; 15(11):19330-19341. https://doi.org/10.3390/ijms151119330
Chicago/Turabian StyleZhang, Yu, Yan Sun, Tao Chen, Hailong Hu, Wanqin Xie, Zhihui Qiao, Na Ding, Linguo Xie, Sheng Li, Wenlong Wang, and et al. 2014. "Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population" International Journal of Molecular Sciences 15, no. 11: 19330-19341. https://doi.org/10.3390/ijms151119330