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Int. J. Mol. Sci. 2014, 15(12), 21687-21702;

Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China

Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110013, China
Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China
Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China
Author to whom correspondence should be addressed.
Received: 21 September 2014 / Revised: 3 November 2014 / Accepted: 12 November 2014 / Published: 25 November 2014
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
Full-Text   |   PDF [729 KB, uploaded 25 November 2014]


Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C677T and MTRR A66G polymorphisms with MetS, 692 Chinese Han subjects with MetS and 878 controls were recruited. The component traits of MetS and the MTHFR C677T and MTRR A66G genotypes were determined. A significant association was observed between the MTHFR 677T allele and increased risk of MetS, high fasting blood glucose, high waist circumference, and increasing number of MetS components. The MTRR A66G polymorphism was associated with an increased risk of MetS when combined with the MTHFR 677TT genotype, although there was no association found between MetS and MTRR A66G alone. Furthermore, the MTRR 66GG genotype was associated with high fasting blood glucose and triglycerides. Our data suggest that the MTHFR 677T allele may contribute to an increased risk of MetS in the northern Chinese Han population. The MTRR A66G polymorphism is not associated with MetS. However, it may exacerbate the effect of the MTHFR C677T variant alone. Further large prospective population-based studies are required to confirm our findings. View Full-Text
Keywords: MTHFR; MTRR; polymorphism; metabolic syndrome; China MTHFR; MTRR; polymorphism; metabolic syndrome; China
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yang, B.; Fan, S.; Zhi, X.; Wang, D.; Li, Y.; Wang, Y.; Wang, Y.; Wei, J.; Zheng, Q.; Sun, G. Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China. Int. J. Mol. Sci. 2014, 15, 21687-21702.

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