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Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

Laboratory of Molecular Virology and Oncology, Francesco Balsano Foundation, Rome 00198, Italy
Department of Experimental Oncology, Regina Elena National Cancer Institute IRCCS, Rome 00144, Italy
Department of Internal Medicine and Medical Specialties, Sapienza University, Rome 00161, Italy
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50139, Italy
Institute of Biology, Molecular Medicine and Nanobiotechnologies (IBMN), National Research Council (CNR), Rome 00185, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(10), 18508-18524;
Received: 28 July 2014 / Revised: 25 September 2014 / Accepted: 26 September 2014 / Published: 14 October 2014
(This article belongs to the Special Issue Bioactive Phenolics and Polyphenols)
The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, chosen as a symbol of peace and health. Recently, accumulating experimental, clinical and epidemiological data have provided support to the traditional beliefs of the beneficial effect provided by olive derivates. In particular, the polyphenols present in olive leaves, olives, virgin (unrefined) olive oil and olive mill waste are potent antioxidant and radical scavengers with anti-tumor and anti-inflammatory properties. Here, we review the positive impact on human health of oleuropein, the most prevalent polyphenol present in olives. In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease. View Full-Text
Keywords: olive; oleuropein; Mediterranean diet; polyphenols; antioxidant; anti-inflammatory; anticancer; non-alcoholic fatty liver disease olive; oleuropein; Mediterranean diet; polyphenols; antioxidant; anti-inflammatory; anticancer; non-alcoholic fatty liver disease
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Barbaro, B.; Toietta, G.; Maggio, R.; Arciello, M.; Tarocchi, M.; Galli, A.; Balsano, C. Effects of the Olive-Derived Polyphenol Oleuropein on Human Health. Int. J. Mol. Sci. 2014, 15, 18508-18524.

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