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Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins

Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 406-840, Korea
Department of Polar Sciences, University of Science and Technology, Incheon 406-840, Korea
The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA
Laboratory of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(10), 18253-18266;
Received: 31 July 2014 / Revised: 23 September 2014 / Accepted: 25 September 2014 / Published: 10 October 2014
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells. View Full-Text
Keywords: actin; bacillary dysentery; bacterial proteins; invasin; review; Shigella actin; bacillary dysentery; bacterial proteins; invasin; review; Shigella
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Lee, J.H.; Park, H.; Park, Y.H. Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins. Int. J. Mol. Sci. 2014, 15, 18253-18266.

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