Platelets: Still a Therapeutical Target for Haemostatic Disorders
Programa de Pós-graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói CEP 24210-130, RJ, Brazil
Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24030-215, RJ, Brazil
LabTIF, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-590, RJ, Brazil
Interdisciplinary Center for Biotechnology Research, Federal University of Pampa, Antônio Trilha Avenue, P.O. Box 1847, São Gabriel/RS 97300-000, Brazil
Authors to whom correspondence should be addressed.
Received: 19 June 2014 / Revised: 26 August 2014 / Accepted: 23 September 2014 / Published: 7 October 2014
Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored.
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Geraldo, R.B.; Sathler, P.C.; Lourenço, A.L.; Saito, M.S.; Cabral, L.M.; Rampelotto, P.H.; Castro, H.C. Platelets: Still a Therapeutical Target for Haemostatic Disorders. Int. J. Mol. Sci. 2014, 15, 17901-17919.
Geraldo RB, Sathler PC, Lourenço AL, Saito MS, Cabral LM, Rampelotto PH, Castro HC. Platelets: Still a Therapeutical Target for Haemostatic Disorders. International Journal of Molecular Sciences. 2014; 15(10):17901-17919.
Geraldo, Reinaldo B.; Sathler, Plínio C.; Lourenço, André L.; Saito, Max S.; Cabral, Lucio M.; Rampelotto, Pabulo H.; Castro, Helena C. 2014. "Platelets: Still a Therapeutical Target for Haemostatic Disorders." Int. J. Mol. Sci. 15, no. 10: 17901-17919.
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