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Int. J. Mol. Sci. 2014, 15(10), 17901-17919;

Platelets: Still a Therapeutical Target for Haemostatic Disorders

Programa de Pós-graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói CEP 24210-130, RJ, Brazil
Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24030-215, RJ, Brazil
LabTIF, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-590, RJ, Brazil
Interdisciplinary Center for Biotechnology Research, Federal University of Pampa, Antônio Trilha Avenue, P.O. Box 1847, São Gabriel/RS 97300-000, Brazil
Authors to whom correspondence should be addressed.
Received: 19 June 2014 / Revised: 26 August 2014 / Accepted: 23 September 2014 / Published: 7 October 2014
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [3174 KB, uploaded 24 October 2014]   |  


Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored. View Full-Text
Keywords: platelets; agonists; receptor; thrombosis; aspirin® platelets; agonists; receptor; thrombosis; aspirin®

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Geraldo, R.B.; Sathler, P.C.; Lourenço, A.L.; Saito, M.S.; Cabral, L.M.; Rampelotto, P.H.; Castro, H.C. Platelets: Still a Therapeutical Target for Haemostatic Disorders. Int. J. Mol. Sci. 2014, 15, 17901-17919.

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