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DNA Repair Gene XRCC4 Codon 247 Polymorphism Modified Diffusely Infiltrating Astrocytoma Risk and Prognosis

1
Department of Neurology Medicine, Xia-Men Hospital of Traditional Chinese Medicine, Xiamen 361009, China
2
Department of Medicine, Xia-Men Hospital of Traditional Chinese Medicine, Xiamen 361009, China
3
Department of Neurology Medicine, Guangxi Medical University, Nanning 530021, China
4
Department of Pathology, Youjiang Medical College for Nationalities, Baise 533000, China
5
Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(1), 250-260; https://doi.org/10.3390/ijms15010250
Received: 28 October 2013 / Revised: 1 December 2013 / Accepted: 23 December 2013 / Published: 27 December 2013
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The DNA repair gene X-ray cross-complementary group 4 (XRCC4), an important caretaker of the overall genome stability, is thought to play a major role in human tumorigenesis. We investigated the association between an important polymorphic variant of this gene at codon 247 (rs373409) and diffusely infiltrating astrocytoma (DIA) risk and prognosis. This hospital-based case-control study investigated this association in the Guangxi population. In total, 242 cases with DIA and 358 age-, sex-, and race-matched healthy controls were genotyped using TaqMan-PCR technique. We found a significant difference in the frequency of XRCC4 genotypes between cases and controls. Compared with the homozygote of XRCC4 codon 247 Ala alleles (XRCC4-AA), the genotypes of XRCC4 codon 247 Ser alleles (namely XRCC4-AS or -SS) increased DIA risk (odds ratios [OR], 1.82 and 2.89, respectively). Furthermore, XRCC4 polymorphism was correlated with tumor dedifferentiation of DIA (r = 0.261, p < 0.01). Additionally, this polymorphism modified the overall survival of DIA patients (the median survival times were 26, 14, and 8 months for patients with XRCC4-AA, -AS, and -SS, respectively). Like tumor grade, XRCC4 codon 247 polymorphism was an independent prognostic factor influencing the survival of DIA. These results suggest that XRCC4 codon 247 polymorphism may be associated with DIA risk and prognosis among the Guangxi population. View Full-Text
Keywords: XRCC4; polymorphism; DIA XRCC4; polymorphism; DIA
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MDPI and ACS Style

Lin, Z.-H.; Chen, J.-C.; Wang, Y.-S.; Huang, T.-J.; Wang, J.; Long, X.-D. DNA Repair Gene XRCC4 Codon 247 Polymorphism Modified Diffusely Infiltrating Astrocytoma Risk and Prognosis. Int. J. Mol. Sci. 2014, 15, 250-260. https://doi.org/10.3390/ijms15010250

AMA Style

Lin Z-H, Chen J-C, Wang Y-S, Huang T-J, Wang J, Long X-D. DNA Repair Gene XRCC4 Codon 247 Polymorphism Modified Diffusely Infiltrating Astrocytoma Risk and Prognosis. International Journal of Molecular Sciences. 2014; 15(1):250-260. https://doi.org/10.3390/ijms15010250

Chicago/Turabian Style

Lin, Zhong-Hui, Jin-Chun Chen, Yun-Sun Wang, Teng-Jiao Huang, Jin Wang, and Xi-Dai Long. 2014. "DNA Repair Gene XRCC4 Codon 247 Polymorphism Modified Diffusely Infiltrating Astrocytoma Risk and Prognosis" International Journal of Molecular Sciences 15, no. 1: 250-260. https://doi.org/10.3390/ijms15010250

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