Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease
Abstract
:1. Introduction
2. Results
2.1. Body Weight
2.2. Histopathological Changes in AC
2.3. Chondrocyte Apoptosis
2.4. Correlation between Chondrocyte Apoptosis and AC Degradation
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Histology and Microscopic Scoring
4.3. Caspase-3 Staining
4.4. Terminal Deoxyribonucleotidyl Transferase (TdT)-Mediated dUTP Nick-End Labelling (TUNEL) Staining
4.5. Statistics
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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Zamli, Z.; Adams, M.A.; Tarlton, J.F.; Sharif, M. Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease. Int. J. Mol. Sci. 2013, 14, 17729-17743. https://doi.org/10.3390/ijms140917729
Zamli Z, Adams MA, Tarlton JF, Sharif M. Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease. International Journal of Molecular Sciences. 2013; 14(9):17729-17743. https://doi.org/10.3390/ijms140917729
Chicago/Turabian StyleZamli, Zaitunnatakhin, Michael A. Adams, John F. Tarlton, and Mohammed Sharif. 2013. "Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease" International Journal of Molecular Sciences 14, no. 9: 17729-17743. https://doi.org/10.3390/ijms140917729