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Open AccessArticle

Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles

1
Department of Chemistry, Materials and Chemical Engineering "G. Natta" Polytechnic, 7 Mancinelli Street, 20131 Milan, Italy
2
Interuniversity Center "The Protein Factory," Polytechnic of Milan, ICRM-CNR Milan and Insubria University, 21100 Varese, Italy
3
Ronzoni Institute for Chemical and Biochemical Research, 81 G. Colombo Street, 20133 Milan, Italy
4
Department of Biotechnology and Molecular Sciences, University of Insubria, 3 Dunant Street, 21100 Varese, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(7), 13463-13481; https://doi.org/10.3390/ijms140713463
Received: 1 March 2013 / Revised: 24 May 2013 / Accepted: 14 June 2013 / Published: 27 June 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2013)
Heparin has been conjugated to Fe3O4, Co3O4, and NiO nanoparticles (NPs) through electrostatic interactions, producing colloidal suspensions of hybrid metal oxide heparin NPs that are stable in water. Negative zeta potentials and retention of heparin’s ability to capture toluidine blue indicate that heparin’s negative charges are exposed on the surface of the coated NPs. IR results confirmed the formation of nanohybrids as did NMR experiments, which were also interpreted on the basis of toluidine blue tests. Transmission electron microscopy results revealed that the heparin coating does not modify the shape or dimension of the NPs. Dynamic light scattering and negative zeta potential measurements confirmed that heparin surface functionalisation is an effective strategy to prevent NP aggregation. View Full-Text
Keywords: heparin; transition metal oxide nanoparticles; organic inorganic nanostructures; electrostatic interaction; NMR spectroscopy; microscopy heparin; transition metal oxide nanoparticles; organic inorganic nanostructures; electrostatic interaction; NMR spectroscopy; microscopy
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MDPI and ACS Style

Vismara, E.; Valerio, A.; Coletti, A.; Torri, G.; Bertini, S.; Eisele, G.; Gornati, R.; Bernardini, G. Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles. Int. J. Mol. Sci. 2013, 14, 13463-13481.

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