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Open AccessReview

The Role of F-Box Proteins during Viral Infection

Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21944-970, Brazil
Department of Microbiology/BIOAGRO, Federal University of Viçosa, Viçosa, MG 36570-000, Brazil
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(2), 4030-4049;
Received: 23 October 2012 / Revised: 14 December 2012 / Accepted: 17 January 2013 / Published: 18 February 2013
(This article belongs to the Special Issue Advances in Molecular Plant Biology)
PDF [207 KB, uploaded 19 June 2014]


The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions. View Full-Text
Keywords: F-box; SCF complex; virus–host interactions; viral infection F-box; SCF complex; virus–host interactions; viral infection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Correa, R.L.; Bruckner, F.P.; De Souza Cascardo, R.; Alfenas-Zerbini, P. The Role of F-Box Proteins during Viral Infection. Int. J. Mol. Sci. 2013, 14, 4030-4049.

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