Next Article in Journal
Non-Coding RNAs: The “Dark Matter” of Cardiovascular Pathophysiology
Next Article in Special Issue
Structural Insights into a Novel Interkingdom Signaling Circuit by Cartography of the Ligand-Binding Sites of the Homologous Quorum Sensing LuxR-Family
Previous Article in Journal
Eleven Novel Polymorphic Microsatellite Loci for Oval Squid Sepioteuthis Lessoniana (Shiro-Ika Type)
Previous Article in Special Issue
Choosing an Appropriate Infection Model to Study Quorum Sensing Inhibition in Pseudomonas Infections
Open AccessArticle

N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers

1
Centre National de la Recherche Scientifique, Institut des Sciences du Végétal, UPR 2355, Gif-sur-Yvette 91198, France
2
FN3PT/RD3PT, Fédération Nationale des Producteurs de Plants de Pomme de terre, 43-45 Rue de Naples, Paris F-75008, France
3
INSA Lyon, ICBMS, UMR 5246, CNRS, Université Lyon 1, INSA-Lyon, CPE-Lyon, Bât J. Verne, 20 av A. Einstein, 69621 Villeurbanne Cedex, France
4
Service de Chimiothèque, ICBMS, UMR 5246, CNRS, Université Lyon 1, INSA-Lyon, CPE-Lyon, Bât Curien, 43 bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
5
Institut National de la Recherche Agronomique, UMR 1349IGEPP, Le Rheu F-35653, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(10), 19976-19986; https://doi.org/10.3390/ijms141019976
Received: 31 May 2013 / Revised: 16 September 2013 / Accepted: 17 September 2013 / Published: 8 October 2013
(This article belongs to the Special Issue Quorum Sensing Research in Microbial Systems)
Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. Four N,N’-bisalkylated imidazolium salts were identified as QSIs; they were active at the µM range. In potato tuber assays, two of them were able to decrease the severity of the symptoms provoked by P. atrosepticum. This work extends the range of the QSIs acting on the Pectobacterium-induced soft-rot disease. View Full-Text
Keywords: N-acylhomoserine lactone; quorum-sensing; quorum-sensing inhibitor; Pectobacterium; soft-rot; potato tuber N-acylhomoserine lactone; quorum-sensing; quorum-sensing inhibitor; Pectobacterium; soft-rot; potato tuber
Show Figures

Graphical abstract

MDPI and ACS Style

Des Essarts, Y.R.; Sabbah, M.; Comte, A.; Soulère, L.; Queneau, Y.; Dessaux, Y.; Hélias, V.; Faure, D. N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers. Int. J. Mol. Sci. 2013, 14, 19976-19986. https://doi.org/10.3390/ijms141019976

AMA Style

Des Essarts YR, Sabbah M, Comte A, Soulère L, Queneau Y, Dessaux Y, Hélias V, Faure D. N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers. International Journal of Molecular Sciences. 2013; 14(10):19976-19986. https://doi.org/10.3390/ijms141019976

Chicago/Turabian Style

Des Essarts, Yannick R.; Sabbah, Mohamad; Comte, Arnaud; Soulère, Laurent; Queneau, Yves; Dessaux, Yves; Hélias, Valérie; Faure, Denis. 2013. "N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers" Int. J. Mol. Sci. 14, no. 10: 19976-19986. https://doi.org/10.3390/ijms141019976

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop