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Int. J. Mol. Sci. 2013, 14(9), 19309-19340;

Choosing an Appropriate Infection Model to Study Quorum Sensing Inhibition in Pseudomonas Infections

Department of Pharmaceutical Biology, University of Groningen, Groningen 9713AV, The Netherlands
Author to whom correspondence should be addressed.
Received: 5 July 2013 / Revised: 13 September 2013 / Accepted: 17 September 2013 / Published: 23 September 2013
(This article belongs to the Special Issue Quorum Sensing Research in Microbial Systems)
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Bacteria, although considered for decades to be antisocial organisms whose sole purpose is to find nutrients and multiply are, in fact, highly communicative organisms. Referred to as quorum sensing, cell-to-cell communication mechanisms have been adopted by bacteria in order to co-ordinate their gene expression. By behaving as a community rather than as individuals, bacteria can simultaneously switch on their virulence factor production and establish successful infections in eukaryotes. Understanding pathogen-host interactions requires the use of infection models. As the use of rodents is limited, for ethical considerations and the high costs associated with their use, alternative models based on invertebrates have been developed. Invertebrate models have the benefits of low handling costs, limited space requirements and rapid generation of results. This review presents examples of such models available for studying the pathogenicity of the Gram-negative bacterium Pseudomonas aeruginosa. Quorum sensing interference, known as quorum quenching, suggests a promising disease-control strategy since quorum-quenching mechanisms appear to play important roles in microbe-microbe and host-pathogen interactions. Examples of natural and synthetic quorum sensing inhibitors and their potential as antimicrobials in Pseudomonas-related infections are discussed in the second part of this review. View Full-Text
Keywords: Pseudomonas aeruginosa; quorum sensing inhibition; animal models Pseudomonas aeruginosa; quorum sensing inhibition; animal models

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Papaioannou, E.; Utari, P.D.; Quax, W.J. Choosing an Appropriate Infection Model to Study Quorum Sensing Inhibition in Pseudomonas Infections. Int. J. Mol. Sci. 2013, 14, 19309-19340.

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