Next Article in Journal
Non-Coding RNAs in Muscle Dystrophies
Next Article in Special Issue
A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin
Previous Article in Journal
Advanced Knowledge of Three Important Classes of Grape Phenolics: Anthocyanins, Stilbenes and Flavonols
Previous Article in Special Issue
The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients
Article

BTG1 Expression Correlates with the Pathogenesis and Progression of Ovarian Carcinomas

1
Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
2
Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
3
Clinical Cancer Institute, Kanagawa Cancer Center, Yokohama 241-0815, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(10), 19670-19680; https://doi.org/10.3390/ijms141019670
Received: 13 May 2013 / Revised: 5 September 2013 / Accepted: 6 September 2013 / Published: 27 September 2013
(This article belongs to the Special Issue Advances in Cancer Diagnosis)
BTG (B-cell translocation gene) can inhibit cell proliferation, metastasis, and angiogenesis and regulate cell cycle progression and differentiation in a variety of cell types. We aimed to clarify the role of BTG1 in ovarian carcinogenesis and progression. A BTG1-expressing plasmid was transfected into ovarian carcinoma cells and their phenotypes and related proteins were examined. BTG1 mRNA expression was detected in ovarian normal tissue (n = 17), ovarian benign tumors (n = 12), and ovarian carcinoma (n = 64) using real-time RT-PCR. Ectopic BTG1 expression resulted in lower growth rate, high cisplatin sensitivity, G1 arrest, apoptosis, and decreased migration and invasion. Phosphoinositide 3-kinase, protein kinase B, Bcl-xL, survivin, vascular endothelial growth factor, and matrix metalloproteinase-2 mRNA and protein expression was reduced in transfectants as compared to control cells. There was higher expression of BTG1 mRNA in normal tissue than in carcinoma tissue (p = 0.001) and in benign tumors than in carcinoma tissue (p = 0.027). BTG1 mRNA expression in International Federation of Gynecology and Obstetrics (FIGO) stage I/II ovarian carcinomas was higher than that in FIGO stage III/IV ovarian carcinomas (p = 0.038). Altered BTG1 expression might play a role in the pathogenesis and progression of ovarian carcinoma by modulating proliferation, migration, invasion, the cell cycle, and apoptosis. View Full-Text
Keywords: ovarian carcinoma; BTG1; phenotypes; tumorigenesis; progression ovarian carcinoma; BTG1; phenotypes; tumorigenesis; progression
Show Figures

MDPI and ACS Style

Zhao, Y.; Gou, W.-F.; Chen, S.; Takano, Y.; Xiu, Y.-L.; Zheng, H.-C. BTG1 Expression Correlates with the Pathogenesis and Progression of Ovarian Carcinomas. Int. J. Mol. Sci. 2013, 14, 19670-19680. https://doi.org/10.3390/ijms141019670

AMA Style

Zhao Y, Gou W-F, Chen S, Takano Y, Xiu Y-L, Zheng H-C. BTG1 Expression Correlates with the Pathogenesis and Progression of Ovarian Carcinomas. International Journal of Molecular Sciences. 2013; 14(10):19670-19680. https://doi.org/10.3390/ijms141019670

Chicago/Turabian Style

Zhao, Yang; Gou, Wen-Feng; Chen, Shuo; Takano, Yasuo; Xiu, Yin-Ling; Zheng, Hua-Chuan. 2013. "BTG1 Expression Correlates with the Pathogenesis and Progression of Ovarian Carcinomas" Int. J. Mol. Sci. 14, no. 10: 19670-19680. https://doi.org/10.3390/ijms141019670

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop