Database Survey of Anti-Inflammatory Plants in South America: A Review
Abstract
:1. Introduction
2. Results and Discussion
3. Material and Methods
4. Conclusion
Acknowledgments
References
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Family and Botanical name | Country | Part used | Type of extract | Model assay/way of route | Organism tested | Activity | Ref. |
---|---|---|---|---|---|---|---|
Acanthaceae | |||||||
Justicia pectoralis var. stenophylla | Brazil | Dried leaf | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [84] |
Brazil | Dried leaf | Hexane-acetone | Dextran-induced pedal edema/Intragastric | Rat | Inactive | [84] | |
Agavaceae | |||||||
Cordyline dracaenoides | Brazil | Dried rhizome | EtOH-H2O (50%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [85] |
Alismataceae | |||||||
Echinodorus grandiflorus | Brazil | Dried rhizome | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [86] |
Brazil | Dried rhizome | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [86] | |
Amaranthaceae | |||||||
Alternanthera brasiliana | Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Route not given | Rat | Inactive | [87] |
Pfaffia glomerata | Brazil | Dried root | EtOH (60%) ext | Acetic acid-induced pedal edema/Intragastric | Mouse | Active | [88] |
Brazil | Dried root | EtOH (60%) ext | Acetic acid-induced pedal edema/IP | Mouse | Active | [88] | |
Pfaffia iresinoides | Brazil | Dried root | Saponin fraction | Carrageenan-induced pleurisy/Intragastric | Rat | Active | [89] |
Brazil | Dried root | H2O ext | Carrageenan-induced pleurisy/Intragastric | Rat | Active | [89] | |
Brazil | Dried root | H2O ext | Cotton pellet granuloma/Intragastric | Rat | Inactive | [89] | |
Brazil | Dried root | Saponin fraction | Cotton pellet granuloma/Intragastric | Rat | Active | [89] | |
Pfaffia paniculata | Brazil | Dried root | EtOH (20%) ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [90] |
Brazil | Dried root | EtOH (60%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [91] | |
Pfaffia stenophylla | Brazil | Dried root | EtOH (20%) ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [90] |
Anacardiaceae | |||||||
Anacardium occidentale | Brazil | Dried bark | Shell | Carrageenan-induced pedal edema/Gastric intubation | Rat | Active | [92] |
Brazil | Dried bark | Shell | Dextran-induced pedal edema/Gastric intubation | Rat | Inactive | [92] | |
Brazil | Dried bark | Shell | Cotton pellet granuloma/IP | Rat | Active | [92] | |
Brazil | Dried bark | Shell | Dextran-induced pedal edema/IP | Rat | Active | [92] | |
Brazil | Dried bark | Shell | Carrageenan-induced pedal edema/IP | Rat | Active | [92] | |
Brazil | Dried bark | Isopropanol-H2O (1:1) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [92] | |
Brazil | Dried bark | Shell | Number of leukocytes in exudate/IP | Rat | Active | [92] | |
Astronium urundeuva | Brazil | Stembark | EtoAc ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [93] |
Brazil | Dried bark | Tannin fraction | Dextran-induced pedal edema/IP | Rat | Active | [93] | |
Brazil | Dried bark | Tannin fraction | Carrageenan-induced pedal edema/IP | Mouse | Active | [93] | |
Brazil | Dried bark | Tannin fraction | Cyclophosphamide-induced hemorrhagic cystitis/IP | Rat | Active | [93] | |
Brazil | Stembark | EtoAc ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [93] | |
Spondias mombin | Venezuela | Dried bark | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [94] |
Apocynaceae | |||||||
Bonafousia longituba | Ecuador | Dried part not specified | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] |
Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [95] | |
Ecuador | Dried part not specified | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [96] | |
Ecuador | Dried part not specified | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [96] | |
Ervatamia coronaria | Brazil | Dried stem | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [97] |
Brazil | Dried stem | EtOH (95%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [97] | |
Brazil | Dried stem | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [97] | |
Himatanthus sucuuba | Brazil | Latex (unspec part) | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [98] |
Mandevilla velutina | Brazil | Dried rhizome | Aqueous-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [99] |
Brazil | Dried rhizome | Aqueous-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [99] | |
Brazil | Dried rhizome | Aqueous-alcoholic ext | 5-HT-induced pedal edema/Intragastric | Rat | Inactive | [99] | |
Brazil | Dried rhizome | Aqueous-alcoholic ext | Carrageenan-induced pedal edema/IP | Rat | Active | [99] | |
Brazil | Dried rhizome | Aqueous-alcoholic ext | Snake venom-induced pedal edema/Intragastric | Rat | Inactive | [99] | |
Brazil | Dried rhizome | Aqueous-alcoholic ext | Platelet aggregating factor-acether induced pedal edema/Intragastric | Rat | Inactive | [99] | |
Brazil | Dried entire plant | EtOH (95%) ext | Arachidonic-acid induced ear edema/Intragastric | Mouse | Active | [100] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Bradykinin-induced pedal edema/Intragastric | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Carrageenan-induced pedal edema/5-HT-induced pedal edema/Intragastric | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Dextran-induced pedal edema/Intragastric | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Cellulose sulfate induced rat paw edema/Intragastric | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Paltelet aggretating factor-acether induced rat paw edema/Intragastric | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Zymosan indued rat paw edema/Intragastric | Rat | Active | [101] | |
Brazil | Frozen rhizome | EtOH H2O (50%) ext | Bothrops jararaca induced rat paw edema/Intragastric | Rat | Inactive | [101] | |
Peschiera australis var. australis | Brazil | Dried leaf | EtOH (100%) ext | Carrageenan-induced paw edema/IP | Rat | Active | [102] |
Brazil | Dried leaf | H2O ext | Carrageenan-induced paw edema/IP | Rat | Active | [102] | |
Peschiera vanheurckii | Peru | Dried stembark | EtOH (100%) ext | EPP-induced rat ear oedema/External | Rat | Active | [103] |
Araliaceae | |||||||
Hedera helix | Uruguay | Dried leaf | EtOH (95%) ext | **/Oral | Human adult | Active | [104] |
Arecaceae | |||||||
Orbignya phalerata | Brazil | Dried fruit | CHCl3 ext | Cotton pellet granuloma/Intragastric | Rat | Active | [105] |
Brazil | Dried fruit | CHCl3 ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [105] | |
Brazil | Dried fruit | CHCl3 ext | Carrageenan-induced pedal edema/IP | Rat | Active | [105] | |
Aristolochiaceae | |||||||
Aristolochia triangularis | Argentina | Dried root | MeOH ext | Croton oil-induced edema/External | Mouse | Active | [106] |
Argentina | Dried root | CH2Cl2 ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried root | H2O ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried root | H2O ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Argentina | Dried root | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Argentina | Dried root | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [106] | |
Asclepiadaceae | |||||||
Marsdenia cundurango | Ecuador | Part not specified | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [96] |
Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] | |
Asteraceae | |||||||
Achyrocline satureioides | Brazil | Dried inflorescence | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [107] |
Brazil | Dried inflorescence | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [107] | |
Brazil | Dried inflorescence | Hot H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [107] | |
Brazil | Dried inflorescence | EtOH (95%) ext | Croton oil ear edema test/External | Mouse | Active | [107] | |
Brazil | Dried inflorescence | H2O ext | Croton oil ear edema test/External | Mouse | Active | [107] | |
Brazil | Dried inflorescence | Hot H2O ext | Croton oil ear edema test/External | Mouse | Active | [107] | |
Ageratum conyzoides | Brazil | Dried leaf | EtOH (70%) ext | Formalin-induced pedal edema/Intragastric | Rat | Active | [62] |
Brazil | Dried leaf | EtOH (70%) ext | Cotton pellet granuloma/Intragastric | Rat | Active | [62] | |
Brazil | Dried leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/SC | Rat | Active | [62] | |
Brazil | Dried leaf | Hydro-alcoholic ext | Formalin-induced pedal edema/Intragastric | Rat | Active | [65] | |
Brazil | Dried leaf | Hydro-alcoholic ext | Cotton pellet granuloma/Intragastric | Rat | Active | [65] | |
Brazil | Dried leaf | EtOH (70%) ext | Yeast-induced inflammation of the paw/IP | Rat | Active | [108] | |
Ambrosia tenuifolia | Argentina | Dried aerial parts | CH2Cl2 ext | Croton oil-induced edema/External | Mouse | Active | [106] |
Argentina | Dried aerial parts | MeOH ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried aerial parts | H2O ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [106] | |
Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Argentina | Dried aerial parts | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Artemisia copa | Argentina | Dried entire plant | Hot H2O ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] |
Argentina | Dried entire plant | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] | |
Argentina | Dried entire plant | MeOH ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] | |
Argentina | Dried aerial parts | H2O ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [71] | |
Argentina | Dried aerial parts | CH2Cl2 ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [71] | |
Baccharis articulata | Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [110] |
Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [110] | |
Baccharis crispa | Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [110] |
Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [110] | |
Baccharis decussata | Colombia | Dried leaf | MeOH ext | **/Route not given | ** | Active | [111] |
Baccharis incarum | Argentina | Dried entire plant | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Rat | Active | [109] |
Argentina | Dried entire plant | MeOH ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] | |
Argentina | Dried entire plant | Hot H2O ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] | |
Baccharis medullosa | Argentina | Dried aerial parts | CHCl3 ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [112] |
Argentina | Dried aerial parts | EtoAc ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [112] | |
Argentina | Dried aerial parts | CCl4 | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [112] | |
Argentina | Dried aerial parts | Hexane ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [112] | |
Baccharis rufescens | Argentina | Dried aerial parts | Hexane ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [112] |
Argentina | Dried aerial parts | Acetone ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [112] | |
Argentina | Dried aerial parts | CHCl3 ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [112] | |
Baccharis trimera | Uruguay | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [110] |
Uruguay | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [110] | |
Uruguay | Dried aerial parts | Butanol ext | Carrageenan-induced edema in rat paw/IP | Rat | Active | [113] | |
Uruguay | Dried aerial parts | Butanol ext | Dextran-induced edema in rat paw/IP | Rat | Active | [113] | |
Uruguay | Dried aerial parts | Butanol ext | Arachindonic acid-induced edema in pat paw/IP | Rat | Equivocal | [113] | |
Uruguay | Dried aerial parts | Butanol ext | C16-PAF-induced edema/IP | Rat | Weak activity | [113] | |
Uruguay | Dried aerial parts | Butanol ext | Zymosan-induced edema in rat paw/IP | Rat | Equivocal | [113] | |
Baccharis trinervis | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [95] |
Baccharis tucumanensis | Argentina | Dried aerial parts | H2O ext | Croton oil-induced edema/External | Mouse | Active | [106] |
Argentina | Dried aerial parts | CH2Cl2 ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried aerial parts | MeOH ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried aerial parts | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [106] | |
Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Argentina | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Bidens pilosa | Brazil | Dried leaf | MeOH ext | Zymosan-induced pedal edema/IP | Mouse | Active | [114] |
Bidens subalternans | Argentina | Dried entire plant | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Weak activity | [115] |
Argentina | Dried entire plant | CHcl3 ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [115] | |
Centaurea chilensis | Chile | Dried aerial parts | MeOH ext | **/Intragastric | Guinea pig | Active | [116] |
Chile | Dried aerial parts | CHCl3 ext | **/Intragastric | Guinea pig | Active | [116] | |
Chromolaena christieana | Argentina | Dried aerial parts | MeOH ext | Croton oil-induced edema/External | Mouse | Active | [106] |
Argentina | Dried aerial parts | CH2Cl2 ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried aerial parts | H2O ext | Croton oil-induced edema/External | Mouse | Active | [106] | |
Argentina | Dried aerial parts | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [106] | |
Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [106] | |
Argentina | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Inactive | [106] | |
Conyza bonariensis | Brazil | Aerial part essent oil | Essential oil | LPS-induced leukocyte recruitement/Intragastric | Mouse | Active | [117] |
Conyza floribunda | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [95] |
Conyza sophiifolia | Argentina | Dried aerial parts | Hexane ext | Paw edema test/Route not given | Rat | Active | [118] |
Argentina | Dried aerial parts | Acetone ext | Paw edema test/Route not given | Rat | Active | [118] | |
Argentina | Dried aerial parts | CHCl3 ext | Paw edema test/Route not given | Rat | Active | [118]
| |
Cynara scolymus | Brazil | Fresh leaf | Infusion | Dye diffusion assay/Intragastric | Mouse | Active | [119] |
Elephantopus scaber | Brazil | Fresh leaf | Infusion | Dye diffusion assay/Intragastric | Mouse | Active | [119] |
Brazil | Dried entire plant | EtOH-H2O (50%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [120] | |
Brazil | Dried entire | Decoction | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [120] | |
Eremanthus erythropappus | Brazil | Dried aerial parts | EtOH (95%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [121] |
Eupatorium buniifolium | Argentina | Dried aerial parts | CH2Cl2 ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [122] |
Equador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] | |
Eupatorium inulaefolium var. suaveolens | Argentina | Oven dried aerial parts | CH2Cl2 ext | Phorbol myristate acetate-induced ear | Mouse | Active | [123] |
Inflammation/External | |||||||
Argentina | Oven dried aerial parts | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [123] | |
Gochnatia polymorpha | Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [124] |
Brazil | Dried leaf | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [124] | |
Brazil | Dried leaf | Butanol ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [124] | |
Brazil | Dried leaf | EtoAc ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [124] | |
Brazil | Dried leaf | Dichloromethane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [124] | |
Laennecia sophiifolia | Argentina | Dried aerial parts | Hexane ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [112] |
Argentina | Dried aerial parts | Acetone ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [112] | |
Mikania glomerata | Brazil | Fresh leaf | Infusion | Dye diffusion assay/Intragastric | Mouse | Active | [119] |
Brazil | Dried leaf | EtOH-H2O (1:1) ext | PAF-induced edema/Histamine-induced edema/SC | Rat | Inactive | [125] | |
Brazil | Dried leaf | Dichloromethanol | Carrageenan-induced pleurisy/IP | Mouse | Active | [126] | |
Brazil | Dried leaf | EtOH-H2O (1:1) ext | Serotonin-induced pleural edema/SC | Rat | Inactive | [125] | |
Mutisia kurtzii | Argentina | Dried entire plant | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] |
Argentina | Dried entire plant | MeOH ext | **/IP | Rat | Inactive | [109] | |
Argentina | Dried entire plant | Hot H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [109] | |
Neurolaena lobata | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] |
Pluchea sagittalis | Argentina | Dried entire plant | Hot H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [123] |
Argentina | Dried entire plant | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Rat | Active | [123] | |
Argentina | Oven dried aerial parts | CH2Cl2 ext | Phorbol myristate acetate-induced ear inflammation/External | Mouse | Active | [109] | |
Argentina | Oven dried aerial parts | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [109] | |
Argentina | Dried entire plant | MeOH ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [109] | |
Porophyllum ruderale | Brazil | Aerial part essent oil | Essential oil | LPS-induced leukocyte recruitement/Intragastric | Mouse | Active | [117] |
Proustia pyrifolia | Chile | Dried aerial parts | CH2Cl2 ext | Acetic acid-induced pedal edema/External | Mouse | Active | [59] |
Chile | Dried aerial parts | CH2Cl2 ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [59] | |
Chile | Dried aerial parts | MeOH ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [59] | |
Chile | Dried aerial parts | MeOH ext | Acetic acid-induced pedal edema/External | Mouse | Active | [59] | |
Chile | Dried aerial parts | Hexane ext | Acetic acid-induced pedal edema/External | Mouse | Active | [59] | |
Chile | Dried aerial parts | Hexane ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [59] | |
Synedrella nodiflora | Venezuela | Dried leaf | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [94] |
Venezuela | Dried leaf | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [94] | |
Tagetes pusilla | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] |
Tanacetum vulgare | Argentina | Dried aerial parts | Dichloromethane ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [127] |
Argentina | Dried aerial parts | EtOH (100%) ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Weak activity | [128] | |
Argentina | Dried aerial parts | CHCl3 ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [128] | |
Vanillosmopsis arborea | Brazil | Dried trunkwood | Essential oil | **/Gastric intubation | Mouse | Active | [129] |
Bignoniaceae | |||||||
Adenocalymma alliacea | Peru | Dried root + stem | EtOH (100%) ext | EPP-induced rat ear oedema/External | Rat | Weak activity | [103] |
Tabebuia impetiginosa | Brazil | Dried bark | Type ext not stated | Formalin-induced pedal edema/Route not given | Rat | Active | [130] |
Tecoma sambucifolia | Peru | Dried flowers | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [131] |
Peru | Dried flowers | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [131] | |
Peru | Dried perianth | H2O ext | Carrageenan-induced pedal edema/IP | Rat | Active | [131] | |
Peru | Dried perianth | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [131] | |
Tynnanthus myrianthus | Peru | Dried part not specified | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [132] |
Boraginaceae | |||||||
Auxemma oncocalyx | Brazil | Dried heartwood | Quinone fraction | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [133] |
Brazil | Dried heartwood | Quinone fraction | Dextran-induced pedal edema/IP | Rat | Active | [133] | |
Brazil | Dried heartwood | Quinone fraction | Carrageenan-induced pedal edema/IP | Rat | Active | [133] | |
Cordia verbenacea | Brazil | Freeze-dried leaf | Lyophilized extract | Miconazole-induced edema/Intragastric | Rat | Active | [134] |
Brazil | Freeze-dried leaf | Lyophilized extract | Nystatin-induced edema/External | Rat | Active | [134] | |
Brazil | Fresh leaf | EtOH (70%) ext | Cotton pellet granuloma/External | Rat | Active | [135] | |
Brazil | Fresh leaf | EtOH (70%) ext | Cotton pellet granuloma/Intragastric | Rat | Active | [135] | |
Brazil | Dried leaf | EtOH (70%) ext | Croton oil-induced edema/External | Mouse | Active | [136] | |
Brazil | Dried leaf | EtOH (70%) ext | Nystatin-induced pedal edema/Gastric intubation | Rat | Active | [136] | |
Brazil | Dried leaf | EtOH (70%) ext | Cold stress and carrageenin-induced edema combined/Gastric intubation | Rat | Active | [136] | |
Brazil | Fresh leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/Oral | Rat | Active | [137] | |
Brazil | Fresh leaf | EtOH (70%) ext | Cotton pellet granuloma/Oral | Rat | Active | [137] | |
Brazil | Freeze-dried leaf | Lyophilized extract | Nystatin-induced edema/External | Rat | Active | [134] | |
Symphytum officinale | Brazil | Dried leaf | Aqueous high speed supernatant | Carrageenan-induced pedal edema/Gastric intubation | Rat | Inactive | [138] |
Bromeliaceae | |||||||
Nidularium procerum | Brazil | Dried leaf | H2O ext | LPS-induced inflammatory/IP | Mouse | Active | [139] |
Tillandsia streptocarpa | Brazil | Dried entire plant | MeOH ext | Croton oil-induced edema/External | Mouse | Active | [140] |
Burseraceae | |||||||
Bursera simaruba | Venezuela | Dried leaf | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [94] |
Venezuela | Dried leaf | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [94] | |
Venezuela | Dried bark | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [94] | |
Venezuela | Dried leaf | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [141] | |
Protium kleinii | Brazil | Dried bark | Ether ext | Arachidonic acid-induced edema/External | Mouse | Inactive | [142] |
Brazil | Dried bark | Ether ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/External | Mouse | Active | [142] | |
Celastraceae | |||||||
Cheiloclinium cognatum | Brazil | Dried rootbark | MeCl2 ext | Croton oil-induced edema/Intragastric | Mouse | Active | [143] |
Maytenus aquifolium | Brazil | Dried leaf/plus piroxican | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [144] |
Brazil | Dried leaf | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [144] | |
Maytenus boaria | Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [145] |
Maytenus ilicifolia | Brazil | Dried leaf | Hexane-acetone | **/Intragastric | Rat | Active | [82] |
Brazil | Dried leaf | EtoAc ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [82] | |
Brazil | Dried leaf | Hexane-acetone | Formalin-induced pedal edema/Intragastric | Mouse | Active | [82] | |
Brazil | Dried leaf | EtoAc ext | Formalin-induced pedal edema/Intragastric | Mouse | Active | [82] | |
Maytenus laevis | Colombia | Bark | EtOH (95%) ext | Carrageenin-induced pedal edema/SC | Rat | Active | [146] |
Maytenus rigida | Brazil | Dried bark | EtOH (95%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [147] |
Chloranthaceae | |||||||
Hedyosmum bonplandianum | Colombia | Dried leaf | Butanol ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [148] |
Clusiaceae | |||||||
Hypericum brasiliense | Brazil | Dried leaf | Type ext not stated | Carrageenan-induced pedal edema/Oral | Rat | Active | [149] |
Convolvulaceae | |||||||
Cuscuta chilensis | Chile | Dried entire plant | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [150] |
Chile | Dried entire plant | Infusion | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [150] | |
Ipomoea fistulosa | Argentina | Oven dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [123] |
Argentina | Oven dried aerial parts | CH2Cl2 ext | Phorbol myristate acetate-induced ear inflammation/External | Mouse | Active | [123] | |
Crassulaceae | |||||||
Bryophyllum calcinum | Brazil | Dried leaf | Lyophilized extract | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [151] |
Kalanchoe brasiliensis | Brazil | Fresh leaf | Plant juice | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [152] |
Brazil | Fresh leaf | Juice | Zymosan-induced inflammation/IP | Mouse | Active | [153] | |
Brazil | Fresh fruit juice (unripe) | Juice | **/IP | Mouse | Active | [154] | |
Cucurbitaceae | |||||||
Cayaponia tayuya | Brazil | Dried root | MeOH ext | Carrageenan-induced pedal edema/Gastric intubation | Mouse | Inactive | [155] |
Brazil | Dried root | CHCl3 ext | Carrageenan-induced pedal edema/Gastric intubation | Mouse | Weak activity | [155] | |
Brazil | Dried root | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Weak activity | [155] | |
Brazil | Dried root | CHCl3 ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [155] | |
Brazil | Dried root | Infusion | Dye diffusion assay/Intragastric | Mouse | Equivocal | [119] | |
Wilbrandia ebracteata | Brazil | Dried root | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Rat | Weak activity | [156] |
Brazil | Dried root | CHCl3 soluble fraction | Carrageenan-induced pleurisy/Intragastric | Mouse | Active | [156] | |
Brazil | Dried root | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Rat | Active | [156] | |
Brazil | Dried root | Chromatographic fraction | Carrageenan-induced pleurisy/IP | Mouse | Active | [156] | |
Brazil | Dried root | CHCl3 soluble fraction | Carrageenan-induced pleurisy/IP | Mouse | Active | [156] | |
Wilbrandia species | Brazil | Dried rhizome | EtOH (70%) ext | Acetic acid-induced pedal edema/Intragastric | Mouse | Active | [157] |
Brazil | Dried rhizome | EtOH (70%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [157] | |
Brazil | Dried rhizome | EtOH (70%) ext | Carrageenan-induced granuloma/Intragastric | Rat | Active | [157] | |
Cyatheaceae | |||||||
Trichipteris procera | Peru | Inner bark | EtOH (95%) ext | **/** | Rabbit | Active | [158] |
Cyperaceae | |||||||
Mariscus pedunculatus | Brazil | Venom | Essential oil | LPS-induced pleurisy model/Intragastric | Mouse | Active | [159] |
Dilleniaceae | |||||||
Curatella americana | Brazil | Dried stembark | Hydro-alcoholic ext | Carrageenan-induced pedal edema/IP | Rat | Active | [160] |
Brazil | Dried stembark | Hydro-alcoholic ext | 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ear inflammation/IP | Mouse | Active | [160] | |
Brazil | Dried stembark | Hydro-alcoholic ext | Capsaicin induced mouse ear edema/IP | Mouse | Active | [160] | |
Equisetaceae | |||||||
Equisetum arvense | Brazil | Stem | EtOH - H2O (1:1) ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [161] |
Erythroxylaceae | |||||||
Erythroxylum argentinum | Brazil | Dried leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [162] |
Brazil | Dried leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [162] | |
Euphorbiaceae | |||||||
Alchornea castaneaefolia | Peru | Dried part not specified | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | ** | [132] |
Peru | Dried stembark | EtOH (100%) ext | Epp-induced rat ear edema/** | Rat | Active | [103] | |
Croton cajucara | Brazil | Bark essential oil | Essential oil | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [163] |
Brazil | Bark essential oil | Essential oil | Cotton pellet granuloma/Intragastric | Rat | Active | [163] | |
Croton celtidifolius | Brazil | Dried bark | H2O ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [164] |
Brazil | Dried bark | EtoAc ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [164] | |
Brazil | Dried bark | EtOH (80%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [164] | |
Brazil | Dried bark | Butanol ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [164] | |
Brazil | Dried bark | EtoAc ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [164] | |
Brazil | Dried bark | H2O ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [164] | |
Brazil | Dried bark | Butanol ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [164] | |
Croton lechleri | Peru | Fresh sap | Latex | **/Iinjection | Rat | Active | [165] |
Ecuador | Freeze-drild latex | ** | Carrageenan-induced pedal edema/IP | Rat | Active | [166] | |
Croton malambo | Venezuela | Dried bark | H2O ext | Albumin-induced edema/IP | Mouse | Active | [167] |
Croton menthodorus | Ecuador | Dried seed | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [96] |
Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [95] | |
Croton pullei var. glabrior | Brazil | Dried leaf | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [78] |
Jatropha elliptica | Brazil | Fresh tuber | EtOH-H2O(50%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [168] |
Brazil | Fresh tuber | EtOH-H2O (50%) ext | Dextran-induced pedal edema/Intragastric | Rat | Inactive | [168] | |
Brazil | Fresh tuber | EtOH-H2O(50%) ext | Serotonin-induced pedal edema/Intragastric | Rat | Active | [168] | |
Phyllanthus amarus | Brazil | Dried aerial parts | Hexane ext | Cfa induced edema/Intragastric | Mouse | Active | [169] |
Phyllanthus carolinensis | Brazil | Dried entire plant | Hydro-alcoholic ext | Formalin-induced pedal edema/IP | Mouse | Active | [170] |
Phyllanthus corcovadensis | Brazil | Dried leaf + root + stem | EtOH-H2O(1:1) ext | Carrageenan-induced pedal edema/vs.dextran-induced pedal edema/IP | Mouse | Inactive | [171] |
Fabaceae | |||||||
Apuleia leiocarpa | Brazil | Fresh bark | Infusion | Dye diffusion assay/Intragastric | Mouse | Active | [119] |
Bauhinia guianensis | Brazil | Dried stembark | CH2Cl2 ext | Dextran-induced pedal edema/IP | Rat | Active | [172] |
Brazil | Dried stembark | CH2Cl2 ext | Histamine-induced edema/IP | Rat | Inactive | [172] | |
Brazil | Dried stembark | EtoAc ext | Histamine-induced edema/IP | Rat | Active | [172] | |
Brazil | Dried stembark | EtoAc ext | Dextran-induced pedal edema/IP | Rat | Active | [172] | |
Brazil | Dried stembark | MeOH ext | Carrageenan-induced pedal edema/IP | Rat | Active | [172] | |
Brazil | Dried stembark | MeOH ext | Dextran-induced pedal edema/IP | Rat | Active | [172] | |
Brazil | Dried stembark | MeOH ext | Histamine-induced edema/IP | Rat | Active | [172] | |
Bauhinia tarapotensis | Ecuador | Dried leaf | H2O ext | Croton oil-induced edema/** | Mouse | Active | [76] |
Ecuador | Dried leaf | Dichloromethane ext | Croton oil-induced edema/** | Mouse | Active | [76] | |
Ecuador | Dried leaf | MeOH ext | Croton oil-induced edema/** | Mouse | Active | [76] | |
Ecuador | Dried leaf | Hexane ext | Croton oil-induced edema/** | Mouse | Active | [76] | |
Ecuador | Dried leaf | CHCl3 ext | Croton oil-induced edema/** | Mouse | Active | [76] | |
Caesalpinia ferrea | Brazil | Dried fruit | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [173] |
Calliandra angustifolia | Peru | Dried bark | EtOH (100%) ext | Epp-induced rat ear edema/** | Rat | Inactive | [103] |
Copaifera cearensis | Brazil | Dried balsam | Oleoresin | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [174] |
Copaifera langsdorfii | Brazil | Dried oleoresin | Resin | Acetic acid-induced colitis/Intragastric | Rat | Active | [174] |
Copaifera species | Brazil | Oleoresin | Oleoresin | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [174] |
Brazil | Oleoresin | Oleoresin | Cotton pellet granuloma/Intragastric | Rat | Active | [174] | |
Brazil | Oleoresin | Oleoresin | Histamine-induced vascular peremability/Intragastric | Rat | Active | [174] | |
Erythrina velutina | Brazil | Dried leaf | Decoction | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [175] |
Brazil | Dried leaf | Decoction | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [175] | |
Brazil | Dried leaf | Decoction | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [175] | |
Erythrina crista-galli | Argentina | Dried aerial parts | Dichloromethane ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/** | Mouse | Active | [176] |
Argentina | Dried aerial parts | MeOH ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/** | Mouse | Active | [176] | |
Argentina | Dried aerial parts | H2O ext | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation/** | Mouse | Active | [176] | |
Argentina | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [176] | |
Argentina | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [176] | |
Argentina | Dried aerial parts | Dichloromethane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [176] | |
Marsypianthes chamaedrys | Brazil | Fresh leaf | Infusion | Dye diffusion assay/Intragastric | Mouse | Active | [119] |
Psoralea glandulosa | Chile | Dried aerial parts | Infusion | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [150] |
Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [150] | |
Chile | Dried aerial parts | Pet ether ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [177] | |
Chile | Dried aerial parts | Dichloromethane ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [177] | |
Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [177] | |
Pterocarpus ulei | Peru | Dried stembark | EtOH (100%) ext | EPP-induced rat ear oedema/** | Rat | Inactive | [103] |
Pterodon emarginatus | Brazil | Dried fruit | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [178] |
Brazil | Dried fruit | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [178] | |
Stryphnodendron adstringens | Brazil | Dried stembark | Acetic acid induced vascular permeability/Intragastric | Mouse | Active | [179] | |
Brazil | Dried stembark | Acetone ext | Dextran-induced pedal edema/carrageenan-induced pedal edema/Intragastric | Rat | Active | [179] | |
Brazil | Dried stembark | Acetone ext | **/Intragastric | Rat | Weak activity | [179] | |
Torresea cearensis | Brazil | Dried stembark | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [180] | |
Flacourtiaceae | |||||||
Casearia sylvestris | Brazil | Fresh bark + leaf | Infusion | Dye diffusion assay/Intragastric | Mouse | Weak activity | [119] |
Gentianaceae | |||||||
Gentianella achalensis | Argentina | Dried aerial parts | Chromatographic fraction | 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ear inflammation/** | Mouse | Active | [181] |
Argentina | Dried aerial parts | Pet ether ext | 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ear inflammation/** | Mouse | Inactive | [181] | |
Argentina | Dried aerial parts | MeOH ext | 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ear inflammation/** | Mouse | Inactive | [181] | |
Argentina | Dried aerial parts | Dichloromethane ext | 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ear inflammation/** | Mouse | Active | [181] | |
Argentina | Dried aerial parts | Dichloromethane ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [181] | |
Argentina | Dried aerial parts | Pet ether ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [181] | |
Argentina | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [181] | |
Lamiaceae | |||||||
Hyptis pectinata | Brazil | Dried leaf | H2O ext | Arachidonic acid-induced edema/Intragastric | Rat | Active | [182] |
Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [182] | |
Lavandula latifolia | Paraguay | Aerial parts | Chromatographic fraction | Carrageenan-induced pedal edema/** | Rat | Active | [183] |
Paraguay | Aerial parts | EtOH (70%) ext | Carrageenan-induced pedal edema/** | Rat | Active | [183] | |
Raphiodon echinus | Brazil | Dried aerial parts | H2O ext | Acetic acid-induced dye diffusion/Intragastric | Mouse | Active | [129] |
Liliaceae | |||||||
Polygonatum punctatum | Argentina | Oven dried aerial parts | CH2Cl2 ext | Phorbol myristate acetate-induced ear inflammation/** | Mouse | Active | [123] |
Argentina | Oven dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Weak activity | [123] | |
Linaceae | |||||||
Vantanea peruviana | Peru | Dried stembark | EtOH (100%) ext | EPP-induced rat ear oedema/** | Rat | Strong activity | [103] |
Loasaceae | |||||||
Mentzelia chilensis | Peru | Dried stem | EtoAc ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [184] |
Peru | Dried stem | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [184] | |
Lythraceae | |||||||
Adenaria floribunda | Peru | Dried stem | EtOH (100%) ext | EPP-induced rat ear oedema/** | Rat | Active | [103] |
Magnoliaceae | |||||||
Talauma ovata | Brazil | Dried leaf | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Inactive | [185] |
Malvaceae | |||||||
Sida cordifolia | Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [186] |
Urena lobata | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [95] |
Meliaceae | |||||||
Guarea guidonia | Brazil | Seed | EtOH (90%) ext | Carrageenan-induced pedal edema/Gastric Intubation | Rat | Active | [187] |
Brazil | Seed | EtOH (90%) ext | Cotton pellet granuloma/Gastric Intubation | Rat | Active | [187] | |
Trichilia glabra | Argentina | Dried leaf | Zymosan-induced immediate inflammation moded/IP | Mouse | Active | [188] | |
Menispermaceae | |||||||
Abuta grandifolia | Peru | Dried part not specified | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | ** | [132] |
Cissampelos sympodialis | Brazil | Dried leaf | EtOH (80%) ext | Capsaicin induced edema/IP | Mouse | Active | [189] |
Brazil | Dried leaf | EtOH (80%) ext | 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced ear inflammation/IP | Mouse | Active | [189] | |
Brazil | Dried leaf | EtOH (80%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [189] | |
Monimiaceae | |||||||
Peumus boldus | Chile | Dried leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [190] |
Moraceae | |||||||
Dorstenia brasiliensis | Brazil | Fresh root | Infusion | Dye diffusion assay/Intragastric | Mouse | Weak activity | [119] |
Myristicaceae | |||||||
Virola pavonis | Peru | Dried vine | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [132] |
Virola peruviana | Peru | Dried part not specified | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [132] |
Eugenia uniflora | Brazil | Fresh leaf | Infusion | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [191] |
Brazil | Fresh leaf | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [191] | |
Brazil | Fresh leaf | Decoction | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [191] | |
Brazil | Dried leaf | Infusion | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [191] | |
Brazil | Dried leaf | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [191] | |
Psidium guineense | Brazil | Fresh leaf essential oil | Essential oil | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [192] |
Olacaceae | |||||||
Heisteria acuminata | Ecuador | Dried part not specified | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Inactive | [96] |
Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] | |
Orchidaceae | |||||||
Catasetum barbatum | Paraguay | Dried aerial parts | EtOH (70%) ext | Carrageenan-induced pedal edema/** | Rat | Active | [193] |
Phytolaccaceae | |||||||
Petiveria alliacea | Brazil | Dried root | EtOH (70%) ext | Croton oil-induced irritation/** | Rat | Active | [194] |
Brazil | Dried root | EtOH (70%) ext | Cotton pellet granuloma/** | Rat | Active | [194] | |
Brazil | Dried root | Hydro-alcoholic ext | Nystatin induced edema/Intragastric | Rat | Active | [195] | |
Brazil | Dried root | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [195] | |
Brazil | Dried root | Lyophilized extract | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [196] | |
Brazil | Dried root | Hydro-alcoholic ext | Cotton pellet granuloma/Intragastric | Rat | Active | [195] | |
Peru | Dried entire plant | EtOH (100%) ext | EPP-induced rat ear oedema/** | Rat | Inactive | [103] | |
Phytolacca bogotensis | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Inactive | [95] |
Ecuador | Dried entire plant | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Inactive | [96] | |
Phytolacca rivinoides | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [95] |
Ecuador | Dried entire plant | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Inactive | [96] | |
Piperaceae | |||||||
Peperomia pellucida | Brazil | Dried aerial | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [197] |
Piper lenticellosum | Ecuador | Dried entire plant | EtOH (100%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [95] |
Ecuador | Dried fruit | CH2Cl2 ext | Mouse | Active | [96] | ||
Piper marginatum | Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [198] |
Plantaginaceae | |||||||
Plantago australis | Brazil | Dried root | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [199] |
Brazil | Dried leaf | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [199] | |
Brazil | Dried fruit | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [199] | |
Plantago major | Brazil | Dried leaf | H2O ext | Croton oil-induced edema/** | Mouse | Inactive | [200] |
Brazil | Dried leaf | H2O ext | Croton oil granuloma/** pouch/Intragastric | Rat | Active | [200] | |
Brazil | Dried leaf | H2O ext | Dextran-induced pedal edema/Intragastric | Rat | Inactive | [200] | |
Brazil | Dried leaf | H2O ext | Carrageenan-induced pleurisy/Intragastric | Rat | Active | [200] | |
Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Weak activity | [200] | |
Polygonaceae | |||||||
Polygonum punctatum | Brazil | Dried entire plant | Decoction | Carrageenan-induced pedal edema/Gastric intubation | Rat | Active | [201] |
Brazil | Dried entire plant | EtOH-H2O (1:1) ext | Carrageenan-induced pedal edema/Gastric intubation | Rat | Active | [201] | |
Brazil | Dried entire plant | EtOH-H2O (1:1) ext | Carrageenan-induced pedal edema/** | Rat | Inactive | [201] | |
Brazil | Dried entire plant | Decoction | Carrageenan-induced pedal edema/** | Rat | Inactive | [201] | |
Polypodiaceae | |||||||
Campyloneurum phyllitidis | Paraguay | Dried leaf | H2O ext | Croton oil-induced edema/** | Mouse | Active | [106] |
Paraguay | Dried leaf | CH2Cl2 ext | Croton oil-induced edema/** | Mouse | Active | [106] | |
Paraguay | Dried leaf | MeOH ext | Croton oil-induced edema/** | Mouse | Active | [106] | |
Paraguay | Dried leaf | H2O ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Paraguay | Dried leaf | MeOH ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Paraguay | Dried leaf | CH2Cl2 ext | Carrageenan-induced pedal edema/IP | Mouse | Active | [106] | |
Proteaceae | |||||||
Lomatia hirsuta | Chile | Dried leaf | Infusion | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [202] |
Rhamnaceae | |||||||
Trevoa trinervis | Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [203] |
Chile | Dried aerial parts | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [203] | |
Chile | Dried aerial parts | Dichloromethane ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [203] | |
Chile | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [203] | |
Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [203] | |
Rosaceae | |||||||
Acaena splendens | Chile | Dried bark + spines | CH2Cl2 ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [204] |
Chile | Dried bark + spines | Infusion | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [204] | |
Chile | Dried bark + spines | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [204] | |
Kageneckia oblonga | Chile | Dried aerial parts | Hexane ext | Acetic acid-induced pedal edema/** | Mouse | Active | [205] |
Chile | Dried aerial parts | CHCl3-MeOH extract (2:1) | Acetic acid-induced pedal edema/** | Mouse | Active | [205] | |
Chile | Dried aerial parts | MeOH ext | Acetic acid-induced pedal edema/** | Mouse | Active | [205] | |
Chile | Dried aerial parts | CHCl3-MeOH extract (2:1) | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [205] | |
Chile | Dried aerial parts | H2O soluble fraction | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [205] | |
Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [205] | |
Chile | Dried aerial parts | Hexane ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Active | [205] | |
Rubiaceae | |||||||
Chiococca brachiata | Brazil | Fresh root | Infusion | Dye diffusion assay/Intragastric | Mouse | active | [119] |
Coutarea hexandra | Brazil | Dried stembark | EtOH (95%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [206] |
Uncaria guianensis | Peru | Dried bark | Lyophilized extract | **/** | Human adult | Active | [207] |
Uncaria tomentosa | Peru | Freeze-dried bark | H2O ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [208] |
Peru | Freeze-dried bark | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [208] | |
Peru | Dried bark | Lyophilized extract | **/IP | Mouse | Active | [209] | |
Peru | Dried bark | Lyophilized extract | **/Oral | Human adult | Active | [209] | |
Peru | Dried bark | H2O ext | Cell Culture | In vitro | Active | [210] | |
Peru | Dried bark | H2O ext | 5-ht-induced pedal edema/Intragastric | Rat | Active | [211] | |
Peru | Dried bark | Lyophilized extract | **/Oral | Human adult | Active | [207] | |
Peru | Dried vine | Type ext not stated | **/Route not given | Human adult | Active | [212] | |
Peru | Dried bark | Pet ether ext | 5-ht-Induced pedal edema/IP | Rat | Active | [213] | |
Peru | Dried bark | H2O ext | Chronic intestinal inflammation induced by indomethacin/** | Rat | Active | [210] | |
Peru | Dried root | Rootbark | Convulsions strychnine-induced/carrageenan-induced pedal edemaI/Intragastric | Rat | Active | [214] | |
Peru | Dried bark | EtoAc ext | 5-ht-Induced pedal edema/Intragastric | Rat | Active | [211] | |
Peru | Part not specified | Type ext not stated | **/** | Human adult | Equivocal | [215] | |
Rutaceae | |||||||
Zanthoxylum chiloperone | Brazil | dried leaf | Pet ether ext | Carrageenan-induced pedal edema/Intragastric | Active | [216] | |
Sapindaceae | |||||||
Dodonaea viscosa | Brazil | Dried leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [217] |
Sapotaceae | |||||||
Bumelia sartorum | Brazil | Dried rootbark | EtOH (95%) ext | Carrageenan-induced pedal edema/Gastric Intubation | Rat | Active | [218] |
Scoparia dulcis | Brazil | Dried entire plant | EtOH (95%) ext | Histamine-induced edema/carrageenan-induced pedal edema/Intragastric | Rat | Active | [219] |
Brazil | Dried entire plant | H2O ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [219] | |
Brazil | Dried entire plant | EtOH (95%) ext | Dextran-induced pedal edema/Intragastric | Rat | Active | [219] | |
Brazil | Dried entire plant | EtOH (95%) ext | Cotton pellet granuloma/Intragastric | Rat | Inactive | [219] | |
Simaroubaceae | |||||||
Simaba cedron | South America | Seed | Ether ext | **/SC | Rat | Inactive | [220] |
South America | Seed | Pet ether ext | **/SC | Rat | Inactive | [220] | |
South America | Seed | EtOH (95%) ext | Cotton pellet granuloma/SC | Rat | Weak activity | [220] | |
South America | Seed | H2O ext | Dextran-induced pedal edema/SC | Rat | Weak activity | [220] | |
Solanaceae | |||||||
Brunfelsia bonodora | Peru | Dried part not specified | EtOH (95%) ext | Carrageenan-induced pedal edema/IP | Rat | Active | [132] |
Brunfelsia uniflora | Brazil | Root | MeOH ext | Carrageenin-induced pedal edema/Oral | Rat | Active | [221] |
Brazil | Root | CHCl3 ext | Data incomplete/Oral | Rat | Active | [222] | |
Brazil | Fresh leaf | Infusion | Dye diffusion assay/Intragastric | Mouse | Inactive | [119] | |
Solanum ligustrinum | Chile | Dried aerial parts | Infusion | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] |
Chile | Dried aerial parts | Decoction | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] | |
Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] | |
Chile | Dried aerial parts | Dichloromethane ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] | |
Chile | Dried aerial parts | H2O ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] | |
Chile | Dried aerial parts | Pet ether ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] | |
Chile | Dried aerial parts | MeOH ext | Carrageenan-induced pedal edema/Intragastric | Guinea pig | Weak activity | [223] | |
Solanum lycocarpum | Brazil | Dried fruit | EtOH (95%) ext | Croton oil-induced edema/Intragastric | Mouse | Active | [224] |
Brazil | Dried fruit | Alkaloid fract | Carrageenan-induced pedal edema/SC | Mouse | Active | [224] | |
Brazil | Dried fruit | Alkaloid fract | Croton oil-induced edema/SC | Mouse | Active | [224] | |
Turneraceae | |||||||
Turnera ulmifolia | Brazil | Dried entire plant | Hydro-alcoholic ext | Cotton pellet granuloma/Intragastric | Rat | Active | [225] |
Brazil | Dried entire plant | EtoAc ext | Carrageenan-induced pedal edema/Intragastric | Rat | Inactive | [225] | |
Verbenaceae | |||||||
Bouchea fluminensis | Brazil | Dried leaf | H2O ext | Carrageenan-induced pedal edema/Route not given | Rat | Active | [87] |
Brazil | dried aerial parts | EtOH (95%) ext | 5-ht-induced pedal edema/Intragastric | Mouse | Active | [226] | |
Brazil | dried aerial parts | EtOH (95%) ext | Histamine-induced edema/Intragastric | Mouse | Active | [226] | |
Brazil | dried aerial parts | EtOH (95%) ext | Carrageenan-induced pedal edema/Intragastric | Mouse | Active | [226] | |
Stachytarpheta cayennensis | Brazil | Dried leaf | EtOH (70%) ext | Carrageenan-induced pedal edema/Intragastric | Rat | Weak activity | [227] |
Brazil | Dried leaf | Infusion | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [227] | |
Brazil | Dried entire plant | H2O ext | Dextran-induced pedal edema/carrageenan-induced pedal edema/histamine-induced edema/Intragastric | Mouse | Inactive | [227] | |
Brazil | Dried leaf | Butanol ext | Carrageenan-induced pedal edema/IP | Salvelinus alpinus | Weak activity | [227] | |
Brazil | Dried leaf | Butanol ext | Carrageenan-induced pedal edema/IP | Rat | Active | [228] | |
Winteraceae | |||||||
Drimys winter | Brazil | Dried bark | Hydro-alcoholic ext | PgE2 induced paw oedma/Intragastric | Rat | Equivocal | [229] |
Brazil | Dried bark | Hydro-alcoholic ext | Histamine-induced edema/Intragastric | Rat | Inactive | [229] | |
Brazil | Dried bark | Hydro-alcoholic ext | Carrageenan-induced pedal edema/Intragastric | Rat | Active | [229] | |
Brazil | Dried bark | Hydro-alcoholic ext | Dextran-induced pedal edema/Intragastric | Rat | Active | [229] | |
Brazil | Dried bark | Hydro-alcoholic ext | Bradykinin-induced pedal edema/Intragastric | Rat | Weak activity | [229] | |
Brazil | Dried bark | Hydro-alcoholic ext | Paw oedema/Intragastric | Rat | Weak activity | [229] | |
Brazil | Dried bark | Hydro-alcoholic ext | Paf-acether induced paw oedema/Intragastric | Rat | Weak activity | [229] | |
Brazil | Dried bark | Hydro-alcoholic ext | Ovalbumine induced paw oedema/Intragastric | Rat | Weak activity | [229] | |
Zingiberaceae | [229] | ||||||
Zingiber officinale | Brazil | Fresh rhizome | Hydro-alcoholic ext | Carrageenan-induced pedal edema/IP | Rat | Active | [230] |
Brazil | Fresh rhizome | Hydro-alcoholic ext | 5-ht-induced pedal edema/IP | Rat | Active | [230] | |
Brazil | Fresh rhizome | Hydro-alcoholic ext | 48180 compound-induced edema/** | Rat | Active | [230] | |
Brazil | Fresh rhizome | Hydro-alcoholic ext | 48180 and 5-ht induced skin edema/IP | Rat | Active | [230] | |
Zygophyllaceae | |||||||
Larrea divaricata | Argentina | Dried leaf | MeOH ext | Cotton pellet granuloma/Intragastric | Rat | Active | [231] |
Argentina | Dried leaf | H2O ext | Peritoneal macrophages/IP | Mouse | Active | [232] |
© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Share and Cite
Lima, G.R.d.M.; Montenegro, C.d.A.; Almeida, C.L.F.d.; Athayde-Filho, P.F.d.; Barbosa-Filho, J.M.; Batista, L.M. Database Survey of Anti-Inflammatory Plants in South America: A Review. Int. J. Mol. Sci. 2011, 12, 2692-2749. https://doi.org/10.3390/ijms12042692
Lima GRdM, Montenegro CdA, Almeida CLFd, Athayde-Filho PFd, Barbosa-Filho JM, Batista LM. Database Survey of Anti-Inflammatory Plants in South America: A Review. International Journal of Molecular Sciences. 2011; 12(4):2692-2749. https://doi.org/10.3390/ijms12042692
Chicago/Turabian StyleLima, Gedson Rodrigues de Morais, Camila de Albuquerque Montenegro, Cynthia Layse Ferreira de Almeida, Petrônio Filgueiras de Athayde-Filho, José Maria Barbosa-Filho, and Leônia Maria Batista. 2011. "Database Survey of Anti-Inflammatory Plants in South America: A Review" International Journal of Molecular Sciences 12, no. 4: 2692-2749. https://doi.org/10.3390/ijms12042692