Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers
Abstract
:1. Introduction
2. UV Radiation and the Skin: Regular Foes and Occasional Friends
3. Fernblock: A Multi-Pronged Approach to Photoprotection
3.1. Formulation and Biological Disposition
3.2. Molecular, Cellular and Clinical Evidence of the Photoprotective Properties of Fernblock
3.2.1. DNA Photoprotection
3.2.2. Anti-Inflammatory Activity
3.2.3. Inhibition of Photoimmunosuppression
3.2.4. Prevention of Matrix Remodeling and Other Cellular Effects
3.2.5. Anti-Skin Tumor Capability
3.3. Potential Use of Fernblock in the Treatment of Pathological Skin Conditions
3.3.1. Idiopathic Photodermatosis
3.3.2. Vitiligo
4. Fernblock: A Road to (Present and Future) Photoprotection
Acknowledgements
References
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Effect | Reference | |
---|---|---|
DNA | Prevents formation of cyclobutane pyrimidine dimmers; | [30] |
Inhibits basal oxidative damage (marker, 8-hydroxy-2′-deoxyguanosine); | [30] | |
Blocks damage to mitochondrial DNA. | [31] | |
Inflammation | Prevents sunburn and erythema; | [24,27,29] |
Blocks TNFα, iNOS, AP-1, NF-κB; | [32] | |
Inhibits expression of COX-2; | [30] | |
Prevents apoptosis. | [32,33] | |
Immunosuppression | Blocks t-UCA isomerization; | [34] |
Enhances natural antioxidant systems; | [35] | |
Prevents depletion of Langerhans cells; | [27,29,35] | |
Preserves LC function. | [36] | |
Other cellular effects | Blocks lipid peroxidation; | [37] |
Inhibits cytoskeletal disarray and MMP expression and activation. | [38,39] |
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Gonzalez, S.; Gilaberte, Y.; Philips, N.; Juarranz, A. Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers. Int. J. Mol. Sci. 2011, 12, 8466-8475. https://doi.org/10.3390/ijms12128466
Gonzalez S, Gilaberte Y, Philips N, Juarranz A. Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers. International Journal of Molecular Sciences. 2011; 12(12):8466-8475. https://doi.org/10.3390/ijms12128466
Chicago/Turabian StyleGonzalez, Salvador, Yolanda Gilaberte, Neena Philips, and Angeles Juarranz. 2011. "Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers" International Journal of Molecular Sciences 12, no. 12: 8466-8475. https://doi.org/10.3390/ijms12128466