Next Article in Journal
Enhanced Differentiation of Three-Gene-Reprogrammed Induced Pluripotent Stem Cells into Adipocytes via Adenoviral-Mediated PGC-1α Overexpression
Next Article in Special Issue
Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers
Previous Article in Journal / Special Issue
The Impact of Membrane Lipid Composition on Macrophage Activation in the Immune Defense against Rhodococcus equi and Pseudomonas aeruginosa
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2011, 12(11), 7529-7553;

Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin

The Coca-Cola Company, P.O. Box 1734, Atlanta, GA 30301, USA
Nuclear Magnetic Resonance Center, Emory University, 1515 Pierce Drive Atlanta, GA 30322, USA
Author to whom correspondence should be addressed.
Received: 8 October 2011 / Revised: 25 October 2011 / Accepted: 26 October 2011 / Published: 3 November 2011
(This article belongs to the Special Issue Advances in Nutraceutical Research)
Full-Text   |   PDF [988 KB, uploaded 19 June 2014]


Steviol glycosidesrebaudioside (reb) A, C and D have low aqueous solubilities. To improve their aqueous solubilities, inclusion complex of steviol glycosides, reb A, C and D and gamma cyclodextrin were prepared by freeze drying method and further characterized by means of differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy. The effect of gamma cyclodextrin on chemical shifts of the steviol glycosides was also studied in proton NMR experiments as well as in solid state 13C CP/MAS NMR experiments. These results indicated that the steviol glycosides were clearly in inclusion complex formation with the gamma cyclodextrin which also results in solubility enhancement of these steviol glycosides. Phase solubility studies showed that amounts of soluble reb A, C and D increased with increasing amounts of gamma cyclodextrin indicating formation of 1:1 stoichiometric and higher order inclusion complexes. View Full-Text
Keywords: steviol glycoside; cyclodextrin; solubility; DSC; FT-IR; Raman; NMR steviol glycoside; cyclodextrin; solubility; DSC; FT-IR; Raman; NMR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Upreti, M.; Strassburger, K.; Chen, Y.L.; Wu, S.; Prakash, I. Solubility Enhancement of Steviol Glycosides and Characterization of Their Inclusion Complexes with Gamma-Cyclodextrin. Int. J. Mol. Sci. 2011, 12, 7529-7553.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top