Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia
Abstract
:1. Introduction
2. Results and Discussion
2.1. Neurobehavioral Deficit Score
2.2. Volume of Cerebral Infarction
2.3. Neuronal Apoptosis
2.4. Caspase-3 Expression
2.5. PARP Expression
2.6. The Concentration of Caspase-3 and PARP in Brain Tissue
2.7. Discussion
3. Experimental Section
3.1. Animal Model of MCAO/R
3.2. Intervention Study
3.3. Neurobehavioral Dysfunction Score
3.4. TTC Staining
3.5. Neuronal Apoptosis Assay
3.6. Immunohistochemical Staining
3.7. Enzyme Linked Immunosorbent Assay (ELISA)
3.8. Statistical Analysis
4. Conclusions
Acknowledgments
References
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Groups | n | Neurological function scores | Infarction volume |
---|---|---|---|
Sham-operation group | 5 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Control group | 5 | 2.16 ± 0.28Δ | 77.32 ± 3.06Δ |
Treatment group | 5 | 1.27 ± 0.26* | 68.73 ± 3.46* |
Groups | n | Cortex | Striatum | Hippocampus |
---|---|---|---|---|
Sham-operation group | 5 | 4.53 ± 1.13 | 3.79 ± 1.36 | 3.67 ± 1.15 |
Control group | 5 | 67.62 ± 8.25Δ | 53.30 ± 6.26Δ | 41.30 ± 4.24 |
Treatment group | 5 | 15.64 ± 4.28* | 14.12 ± 4.46* | 12.13 ± 2.46* |
Groups | n | Cortex | Striatum | Hippocampus |
---|---|---|---|---|
Sham-operation group | 5 | 5.25 ± 1.70 | 4.25 ± 1.95 | 3.75 ± 1.69 |
Control group | 5 | 33.4 ± 4.07Δ | 32.80 ± 3.77Δ | 28.00 ± 3.58 Δ |
Treatment group | 5 | 15.82 ± 3.30* | 14.12 ± 2.83* | 13.22 ± 2.29* |
Groups | n | Cortex | Striatum | Hippocampus |
---|---|---|---|---|
Sham-operation group | 5 | 4.34 ± 1.24 | 3.72 ± 1.18 | 3.28 ± 1.16 |
Control group | 5 | 34.25 ± 4.21Δ | 31.75 ± 3.70Δ | 27.50 ± 3.29 Δ |
Treatment group | 5 | 16.00 ± 2.16* | 15.00 ± 2.58* | 12.20 ± 1.92* |
Sham-operation group | n | Caspase-3 | PARP |
---|---|---|---|
Control group | 5 | 12.35 ± 2.21 | 12.24 ± 2.23 |
Treatment group | 5 | 54.23 ± 7.22Δ | 48.12 ± 5.17Δ |
Sham-operation group | 5 | 30.45 ± 4.44* | 28.36 ± 3.62* |
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Li, Q.; Li, Z.; Xu, X.-y.; Guo, Y.-l.; Du, F. Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia. Int. J. Mol. Sci. 2010, 11, 4580-4590. https://doi.org/10.3390/ijms11114580
Li Q, Li Z, Xu X-y, Guo Y-l, Du F. Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia. International Journal of Molecular Sciences. 2010; 11(11):4580-4590. https://doi.org/10.3390/ijms11114580
Chicago/Turabian StyleLi, Qin, Zhen Li, Xin-ying Xu, Yun-liang Guo, and Fang Du. 2010. "Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia" International Journal of Molecular Sciences 11, no. 11: 4580-4590. https://doi.org/10.3390/ijms11114580