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Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

Department of Neurology, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital, Av de França s/n, 17007 Girona, Spain
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Molecules 2010, 15(12), 9104-9134; https://doi.org/10.3390/molecules15129104
Received: 29 October 2010 / Revised: 29 November 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Neuroprotective Strategies)
It is important to understand the molecular mechanisms underlying neuron death following stroke in order to develop effective neuroprotective strategies. Since studies on human stroke are extremely limited due to the difficulty in collecting post-mortem tissue at different time points after the onset of stroke, brain ischaemia research focuses on information derived from in-vitro models of neuronal death through ischaemic injury [1]. This review aims to provide an update on the different in-vitro stroke models with brain microvascular endothelial cells that are currently being used. These models provide a physiologically relevant tool to screen potential neuroprotective drugs in stroke and to study the molecular mechanisms involved in brain ischaemia. View Full-Text
Keywords: neuroprotection; blood brain barrier; brain endothelial cells; cerebral ischaemia; angiogenesis neuroprotection; blood brain barrier; brain endothelial cells; cerebral ischaemia; angiogenesis
MDPI and ACS Style

Camós, S.; Mallolas, J. Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke. Molecules 2010, 15, 9104-9134.

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