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Int. J. Mol. Sci. 2010, 11(10), 4140-4148;

In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Korea
Digital Dyeing & Finishing Tech, Korea Institute of Industrial Technology, Ansan, 426-791, Korea
Department of Biomedical Sciences, College of Medicine, Catholic University, Seoul, 137-701, Korea
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea
Author to whom correspondence should be addressed.
Received: 28 September 2010 / Revised: 19 October 2010 / Accepted: 19 October 2010 / Published: 25 October 2010
(This article belongs to the Special Issue Chitins)
Full-Text   |   PDF [498 KB, uploaded 19 June 2014]


In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats. View Full-Text
Keywords: electrospun; chitosan; microfibers; scaffold; stem cell electrospun; chitosan; microfibers; scaffold; stem cell
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kang, Y.M.; Lee, B.N.; Ko, J.H.; Kim, G.H.; Kang, K.N.; Kim, D.Y.; Kim, J.H.; Park, Y.H.; Chun, H.J.; Kim, C.H.; Kim, M.S. In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering. Int. J. Mol. Sci. 2010, 11, 4140-4148.

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