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Int. J. Mol. Sci. 2010, 11(1), 222-232;

ERK in Learning and Memory: A Review of Recent Research

Department of Anesthesiology, Affiliated No.4 Hospital of Soochow University, Wuxi, 214062, China
Author to whom correspondence should be addressed.
Received: 16 December 2009 / Revised: 8 January 2010 / Accepted: 10 January 2010 / Published: 13 January 2010
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [208 KB, uploaded 19 June 2014]


The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-activated protein kinase (MAPK) superfamily, which is an important, highly conserved family of enzymes associated with cell membrane receptors and regulative targets. In the central nervous system, there is almost no mature neuronal proliferation and differentiation, but the regulation of MAPK and its upstream and downstream molecular pathways is still widespread, with the ERK signaling pathway being one of the most actively studied signal transduction pathways. It is activated by a variety of cell growth factors and substances which promote mitotic activity, and transmits extracellular signals from the cell surface to the nucleus, which transmission plays an important role in the process of cell proliferation and differentiation. In recent years, accumulating evidence has shown that the ERK signaling pathway has an important link with the higher functions of learning and memory. View Full-Text
Keywords: ERK; learning and memory; neurobiology ERK; learning and memory; neurobiology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Peng, S.; Zhang, Y.; Zhang, J.; Wang, H.; Ren, B. ERK in Learning and Memory: A Review of Recent Research. Int. J. Mol. Sci. 2010, 11, 222-232.

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