Next Article in Journal
Copper-Mediated Leaching of LiNi0.65Co0.25Mn0.10O2 in H3PO4: Thermodynamics, Structural Evolution, and Redox Mechanism
Next Article in Special Issue
Thermophysical Behavior and Molecular Interactions of Caffeine in a Novel Menthol–Resorcinol Type V Deep Eutectic Solvent
Previous Article in Journal
CuO@Pyridine Composite for Efficient Removal of Malachite Green and Cd(II) from Water: Adsorption Performance and Mechanistic Insights
Previous Article in Special Issue
Navigating the Solubility Landscape of APIs in Deep Eutectic Solvents: A Data-Driven Thermodynamic Taxonomy of Solvation Regimes and Mechanisms
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 31
Issue 9
10.3390/molecules31091503
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Synthesis of Pyridines, Quinazolinones and Coumarins in Deep Eutectic Solvents: Principles, Methods and Applications

by
Valentina Bušić
,
Maja Molnar
,
Mario Komar
,
Ivana Tomac
,
Martin Kondža
,
Martina Jakovljević Kovač
,
Mirna Habuda-Stanić
,
Damir Magdić
,
Lahorka Budić
and
Dajana Gašo-Sokač
*
Department of Applied Chemistry and Ecology, Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
*
Author to whom correspondence should be addressed.
Molecules 2026, 31(9), 1503; https://doi.org/10.3390/molecules31091503
Submission received: 27 March 2026 / Revised: 28 April 2026 / Accepted: 29 April 2026 / Published: 30 April 2026
(This article belongs to the Special Issue Deep Eutectic Solvents: Design, Characterization, and Applications)
Browse Figures
Versions Notes

Abstract

The synthesis of heterocyclic compounds such as pyridines, quinazolinones and coumarins is a fundamental area of organic chemistry due to their wide application in the pharmaceutical and chemical industries, agro-industry, and other fields of modern technology. As these compounds are produced in large quantities and have significant industrial importance, the development of sustainable and environmentally friendly synthetic approaches has become a key objective of green chemistry. In this context, this review examines the principles, methods and applications of the sustainable synthesis of pyridines, quinazolinones and coumarins in deep eutectic solvents (DESs), a new class of solvents characterized by low volatility, non-toxicity, ease of preparation and recyclability, often from renewable sources. Special emphasis is placed on synthetic strategies that achieve reaction efficiency while reducing environmental impact, including processes without additional catalysts or with reusable catalysts. The paper provides a comprehensive overview of recent advances and highlights the potential of DESs as a viable alternative to conventional organic solvents in the synthesis of bioactive pyridine, quinazolinone and coumarin compounds.
Keywords: deep eutectic solvents; pyridine compounds; quinazolinone; coumarine; sustainable synthesis deep eutectic solvents; pyridine compounds; quinazolinone; coumarine; sustainable synthesis
Graphical Abstract

Share and Cite

MDPI and ACS Style

Bušić, V.; Molnar, M.; Komar, M.; Tomac, I.; Kondža, M.; Jakovljević Kovač, M.; Habuda-Stanić, M.; Magdić, D.; Budić, L.; Gašo-Sokač, D. Synthesis of Pyridines, Quinazolinones and Coumarins in Deep Eutectic Solvents: Principles, Methods and Applications. Molecules 2026, 31, 1503. https://doi.org/10.3390/molecules31091503

AMA Style

Bušić V, Molnar M, Komar M, Tomac I, Kondža M, Jakovljević Kovač M, Habuda-Stanić M, Magdić D, Budić L, Gašo-Sokač D. Synthesis of Pyridines, Quinazolinones and Coumarins in Deep Eutectic Solvents: Principles, Methods and Applications. Molecules. 2026; 31(9):1503. https://doi.org/10.3390/molecules31091503

Chicago/Turabian Style

Bušić, Valentina, Maja Molnar, Mario Komar, Ivana Tomac, Martin Kondža, Martina Jakovljević Kovač, Mirna Habuda-Stanić, Damir Magdić, Lahorka Budić, and Dajana Gašo-Sokač. 2026. "Synthesis of Pyridines, Quinazolinones and Coumarins in Deep Eutectic Solvents: Principles, Methods and Applications" Molecules 31, no. 9: 1503. https://doi.org/10.3390/molecules31091503

APA Style

Bušić, V., Molnar, M., Komar, M., Tomac, I., Kondža, M., Jakovljević Kovač, M., Habuda-Stanić, M., Magdić, D., Budić, L., & Gašo-Sokač, D. (2026). Synthesis of Pyridines, Quinazolinones and Coumarins in Deep Eutectic Solvents: Principles, Methods and Applications. Molecules, 31(9), 1503. https://doi.org/10.3390/molecules31091503

Article Metrics

Back to TopTop