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Volume 30
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Review

Emerging Applications of Thiol-Based Catalysts in Hydrogen Atom Transfer Reactions: A Comprehensive Review

by
Hao Yang
1,
Yanyan Liao
1,
Hao Guo
2,* and
Ming Wang
1,*
1
School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China
2
Ecological Environment Monitoring and Scientific Research Center, Yellow River Basin Ecology and Environment Administration, Ministry of Ecology and Environment, Zhengzhou 450004, China
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(20), 4058; https://doi.org/10.3390/molecules30204058 (registering DOI)
Submission received: 3 September 2025 / Revised: 6 October 2025 / Accepted: 8 October 2025 / Published: 11 October 2025
(This article belongs to the Special Issue Organosulfur and Organoselenium Chemistry II)
Versions Notes

Abstract

Hydrogen atom transfer (HAT) is a fundamental class of radical transformations that enables the direct generation of open-shell radical intermediates from R–H bonds (R = C, N, etc.), offering unique opportunities for green and sustainable synthesis. Significant progress has been made not only in identifying diverse molecular scaffolds capable of mediating HAT but also in developing synthetic methodologies to achieve precise stereocontrol in these processes. In this context, this review highlights recent advances in the use of sugar-derived compounds, cysteine-containing peptides, and chiral/achiral thiols/thiophenols as catalysts for stereoselective HAT, emphasizing their potential to expand the synthetic utility of HAT in organic transformations.
Keywords: hydrogen atom transfer; thiols/thiophenols; photocatalytic hydrogen atom transfer; thiols/thiophenols; photocatalytic

Share and Cite

MDPI and ACS Style

Yang, H.; Liao, Y.; Guo, H.; Wang, M. Emerging Applications of Thiol-Based Catalysts in Hydrogen Atom Transfer Reactions: A Comprehensive Review. Molecules 2025, 30, 4058. https://doi.org/10.3390/molecules30204058

AMA Style

Yang H, Liao Y, Guo H, Wang M. Emerging Applications of Thiol-Based Catalysts in Hydrogen Atom Transfer Reactions: A Comprehensive Review. Molecules. 2025; 30(20):4058. https://doi.org/10.3390/molecules30204058

Chicago/Turabian Style

Yang, Hao, Yanyan Liao, Hao Guo, and Ming Wang. 2025. "Emerging Applications of Thiol-Based Catalysts in Hydrogen Atom Transfer Reactions: A Comprehensive Review" Molecules 30, no. 20: 4058. https://doi.org/10.3390/molecules30204058

APA Style

Yang, H., Liao, Y., Guo, H., & Wang, M. (2025). Emerging Applications of Thiol-Based Catalysts in Hydrogen Atom Transfer Reactions: A Comprehensive Review. Molecules, 30(20), 4058. https://doi.org/10.3390/molecules30204058

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