Correction: Anderson, R.F.; Qi, W. Coenzyme Q₁₀ as an Inhibitor of Effector Release from One-Electron-Reduced Bioreductive Anticancer Prodrugs. Molecules 2025, 30, 760

In the original publication [1], there was some mistakes in Tables 2 and 3. Unfortunately, the proof for the Molecules paper occurred when one author was away on summer vacation when thy did not have office facilities, meaning that checking proved to be inadequate.

These corrections do not materially change the conclusions derived from the table. This correction was approved by the Academic Editor. The original publication has also been updated.

The corrected Table 2 and Table 3 appear below.

Table 2. Kinetic comparison of electron transfer rate constants in methanol and effector release.

Prodrug D	10−6k20O2 (DH• + O2) 1. /M−1 s−1	10−8k6 (DH• + Idebenone) /M−1 s−1	10−8k6 (DH• + CoQ10) /M−1 s−1	k20O2 × 106[O2]K /s−1	k6 × [Idebenone] 2. /s−1	k6 × [CoQ10] 2. /s−1	kfrag. /s−1
tirapazamine	1.17 ± 0.07	5.06 ± 0.67	7.15 ± 0.40	1.4 ± 0.1	51 ± 7	72 ± 5	29 ± 5
SN30000	2.46 ± 0.44	12.3 ± 0.7	9.50 ± 0.21	2.8 ± 0.6	123 ± 7	91 ± 6	102 ± 2
evofosfamide	24.1 ± 3.1	21.5 ± 0.5	15.9 ± 2.3	~6.5 ± 0.8	215 ± 13	153 ± 12	186 ± 30
tarloxotinib	24.3 ± 1.6	6.13 ± 0.48	8.35 ± 0.15	0.8 ± 0.5	61 ± 5	84 ± 1	85 ± 25

^1. see Figures S2–S5 ^2. [ ] = 100 nM.

Table 2. Kinetic comparison of electron transfer rate constants in methanol and effector release.

Prodrug D	10−6k20O2 (DH• + O2) 1. /M−1 s−1	10−8k6 (DH• + Idebenone) /M−1 s−1	10−8k6 (DH• + CoQ10) /M−1 s−1	k20O2 × 106[O2]K /s−1	k6 × [Idebenone] 2. /s−1	k6 × [CoQ10] 2. /s−1	kfrag. /s−1
tirapazamine	1.17 ± 0.07	5.06 ± 0.67	7.15 ± 0.40	1.4 ± 0.1	51 ± 7	72 ± 5	29 ± 5
SN30000	2.46 ± 0.44	12.3 ± 0.7	9.50 ± 0.21	2.8 ± 0.6	123 ± 7	91 ± 6	102 ± 2
evofosfamide	24.1 ± 3.1	21.5 ± 0.5	15.9 ± 2.3	~6.5 ± 0.8	215 ± 13	153 ± 12	186 ± 30
tarloxotinib	24.3 ± 1.6	6.13 ± 0.48	8.35 ± 0.15	0.8 ± 0.5	61 ± 5	84 ± 1	85 ± 25

^1. see Figures S2–S5 ^2. [ ] = 100 nM.

Table 3. Kinetic comparison of combined electron transfer from prodrug radical anions to O₂ and CoQ₁₀ with k_frag.

Prodrug D	10−6k20O2 (DH• + O2) × 78 μM/s−1	10−8k6 (DH• + CoQ10) × 100 nM/s−1	kfrag. /s−1	Kinetic Ratio (k20O2 + k6′)/kfrag.
tirapazamine	91	72	29	5.62
SN30000	192	95	102	2.81
evofosfamide	1880	159	186	11.0
tarloxotinib	1895	84	85	23.3

Table 3. Kinetic comparison of combined electron transfer from prodrug radical anions to O₂ and CoQ₁₀ with k_frag.

Prodrug D	10−6k20O2 (DH• + O2) × 78 μM/s−1	10−8k6 (DH• + CoQ10) × 100 nM/s−1	kfrag. /s−1	Kinetic Ratio (k20O2 + k6′)/kfrag.
tirapazamine	91	72	29	5.62
SN30000	192	95	102	2.81
evofosfamide	1880	159	186	11.0
tarloxotinib	1895	84	85	23.3