Correction: Anderson, R.F.; Qi, W. Coenzyme Q10 as an Inhibitor of Effector Release from One-Electron-Reduced Bioreductive Anticancer Prodrugs. Molecules 2025, 30, 760

Robert F. Anderson; Wen Qi

doi:10.3390/molecules30173515

and

¹

Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

²

School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

³

Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

^*

Author to whom correspondence should be addressed.

Molecules2025, 30(17), 3515;https://doi.org/10.3390/molecules30173515

Version Notes

Order Reprints

In the original publication [1], there was some mistakes in Tables 2 and 3. Unfortunately, the proof for the Molecules paper occurred when one author was away on summer vacation when they did not have office facilities, meaning that checking proved to be inadequate.

These corrections do not materially change the conclusions derived from the table. This correction was approved by the Academic Editor. The original publication has also been updated.

The corrected Table 2 and Table 3 appear below.

Table 2. Kinetic comparison of electron transfer rate constants in methanol and effector release.

Prodrug D	10⁻⁶k₂₀O₂ (DH• + O₂) ^1. /M⁻¹ s⁻¹	10⁻⁸k₆ (DH• + Idebenone) /M⁻¹ s⁻¹	10⁻⁸k₆ (DH• + CoQ₁₀) /M⁻¹ s⁻¹	k₂₀O₂ × 10⁶[O₂]^K /s⁻¹	k₆ × [Idebenone] ^2. /s⁻¹	k₆ × [CoQ₁₀] ^2. /s⁻¹	k_frag. /s⁻¹
tirapazamine	1.17 ± 0.07	5.06 ± 0.67	7.15 ± 0.40	1.4 ± 0.1	51 ± 7	72 ± 5	29 ± 5
SN30000	2.46 ± 0.44	12.3 ± 0.7	9.50 ± 0.21	2.8 ± 0.6	123 ± 7	91 ± 6	102 ± 2
evofosfamide	24.1 ± 3.1	21.5 ± 0.5	15.9 ± 2.3	~6.5 ± 0.8	215 ± 13	153 ± 12	186 ± 30
tarloxotinib	24.3 ± 1.6	6.13 ± 0.48	8.35 ± 0.15	0.8 ± 0.5	61 ± 5	84 ± 1	85 ± 25

^1. see Figures S2–S5 ^2. [ ] = 100 nM.

Table 3. Kinetic comparison of combined electron transfer from prodrug radical anions to O₂ and CoQ₁₀ with k_frag.

Prodrug D	10⁻⁶k₂₀O₂ (DH• + O₂) × 78 μM/s⁻¹	10⁻⁸k₆ (DH• + CoQ₁₀) × 100 nM/s⁻¹	k_frag. /s⁻¹	Kinetic Ratio (k₂₀O₂ + k₆^′)/k_frag.
tirapazamine	91	72	29	5.62
SN30000	192	95	102	2.81
evofosfamide	1880	159	186	11.0
tarloxotinib	1895	84	85	23.3

Reference

Anderson, R.F.; Qi, W. Coenzyme Q₁₀ as an Inhibitor of Effector Release from One-Electron-Reduced Bioreductive Anticancer Prodrugs. Molecules 2025, 30, 760. [Google Scholar] [CrossRef] [PubMed]

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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Correction: Anderson, R.F.; Qi, W. Coenzyme Q₁₀ as an Inhibitor of Effector Release from One-Electron-Reduced Bioreductive Anticancer Prodrugs. Molecules 2025, 30, 760

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