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Volume 30
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10.3390/molecules30153111
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Review

The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies

by
Joanna Wróblewska
1,*,
Anna Długosz
2,*,
Damian Czarnecki
3,
Wioletta Tomaszewicz
4,
Błażej Błaszak
2,
Joanna Szulc
2 and
Weronika Wróblewska
5
1
Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, Poland
2
Department of Food Industry Technology and Engineering, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, 3 Seminaryjna St., 85-326 Bydgoszcz, Poland
3
Department of Preventive Nursing, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 1 Łukasiewicza St., 85-821 Bydgoszcz, Poland
4
Department of Health Law and Policy, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 20 Świętojańska St., 85-077 Bydgoszcz, Poland
5
Student Scientific Club of Biochemistry and Bioorganic Chemistry, Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, Poland
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(15), 3111; https://doi.org/10.3390/molecules30153111
Submission received: 13 June 2025 / Revised: 17 July 2025 / Accepted: 23 July 2025 / Published: 25 July 2025
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Abstract

Alcohol dependency is a complex and chronic condition that negatively impacts multiple organ systems, including the skin. A key pathological factor in this process is oxidative stress, leading to progressive cellular damage, chronic inflammation, and accelerated cutaneous aging. Alcohol metabolism generates reactive oxygen species (ROS), which overwhelm endogenous antioxidant defenses and contribute to a range of skin alterations, including nonspecific changes such as xerosis, erythema, and wrinkle formation, as well as inflammatory and neoplastic skin disorders. Additionally, alcohol-induced alterations of the skin microbiome may further exacerbate skin barrier dysfunction and inflammatory responses. This review explores the biochemical mechanisms and skin microbiome alterations linking alcohol-induced oxidative stress to skin damage and disease. Furthermore, it evaluates the therapeutic potential of antioxidant-based interventions, both natural and synthetic. Antioxidants may offer protective and regenerative effects by scavenging free radicals, modulating inflammatory responses, and enhancing skin barrier function. The paper aims to provide a comprehensive overview of the molecular and microbial interplay between alcohol, oxidative stress, and skin health, while identifying future directions for targeted antioxidant therapy in individuals with alcohol dependency.
Keywords: alcohol dependency; antioxidant therapy; dietary antioxidants; microbial interactions; oxidative stress; reactive oxygen species; skin disorders alcohol dependency; antioxidant therapy; dietary antioxidants; microbial interactions; oxidative stress; reactive oxygen species; skin disorders

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MDPI and ACS Style

Wróblewska, J.; Długosz, A.; Czarnecki, D.; Tomaszewicz, W.; Błaszak, B.; Szulc, J.; Wróblewska, W. The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies. Molecules 2025, 30, 3111. https://doi.org/10.3390/molecules30153111

AMA Style

Wróblewska J, Długosz A, Czarnecki D, Tomaszewicz W, Błaszak B, Szulc J, Wróblewska W. The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies. Molecules. 2025; 30(15):3111. https://doi.org/10.3390/molecules30153111

Chicago/Turabian Style

Wróblewska, Joanna, Anna Długosz, Damian Czarnecki, Wioletta Tomaszewicz, Błażej Błaszak, Joanna Szulc, and Weronika Wróblewska. 2025. "The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies" Molecules 30, no. 15: 3111. https://doi.org/10.3390/molecules30153111

APA Style

Wróblewska, J., Długosz, A., Czarnecki, D., Tomaszewicz, W., Błaszak, B., Szulc, J., & Wróblewska, W. (2025). The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies. Molecules, 30(15), 3111. https://doi.org/10.3390/molecules30153111

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