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Article

W/O/W Multiple Emulsified Microcapsules Based on Biopolymer Soybean Isolate Proteins: Improving Tannic Acid’s Biocompatibility and Sustained-Release Performance

1
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China
2
Engineering Research Center of Perfume & Aroma and Cosmetics, Ministry of Education, Shanghai 201418, China
3
JAKA Biotechnology Co., Ltd., Shanghai 201500, China
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(11), 2373; https://doi.org/10.3390/molecules30112373
Submission received: 31 March 2025 / Revised: 26 May 2025 / Accepted: 27 May 2025 / Published: 29 May 2025
(This article belongs to the Section Macromolecular Chemistry)

Abstract

Tannic acid (TA) possesses antioxidant, anticancer, and antibacterial properties. However, its pH sensitivity, protein cross-linking properties, and susceptibility to oxidation restrict its application. To address these challenges, W/O/W multiple emulsified TA microcapsules were developed using soybean protein isolate (SPI) as the natural wall material emulsifier through a two-step emulsification and spray drying process. The encapsulation efficiency of the obtained TA microcapsules was 87.6%, and TA’s thermal stability was significantly improved. TA microcapsules effectively reduced the acidity and irritability of TA, eliminated protein flocculation, and enhanced biocompatibility. Notably, the cell viability of the TA microcapsule (>94%) was significantly higher than free TA (65.6%). The storage stability test revealed that the microcapsules maintained structural integrity, with a retention rate of 96% after 10 days of storage. In vitro release studies of TA microcapsules demonstrated a sustained-release effect within 24 h. Simulated digestion studies further elucidated the protective effect of microcapsules on TA during gastric digestion. These multi-structured microcapsules based on SPI effectively address the limitations associated with TA utilization and enhance its potential for dual oral/transdermal administration in biomedical and cosmetic applications.
Keywords: tannic acid; multiple emulsification; biocompatibility; microcapsule; soybean isolate proteins tannic acid; multiple emulsification; biocompatibility; microcapsule; soybean isolate proteins

Share and Cite

MDPI and ACS Style

Zhang, S.; Yan, R.; Zhang, S.; Lu, Y. W/O/W Multiple Emulsified Microcapsules Based on Biopolymer Soybean Isolate Proteins: Improving Tannic Acid’s Biocompatibility and Sustained-Release Performance. Molecules 2025, 30, 2373. https://doi.org/10.3390/molecules30112373

AMA Style

Zhang S, Yan R, Zhang S, Lu Y. W/O/W Multiple Emulsified Microcapsules Based on Biopolymer Soybean Isolate Proteins: Improving Tannic Acid’s Biocompatibility and Sustained-Release Performance. Molecules. 2025; 30(11):2373. https://doi.org/10.3390/molecules30112373

Chicago/Turabian Style

Zhang, Suning, Ruman Yan, Siyu Zhang, and Yina Lu. 2025. "W/O/W Multiple Emulsified Microcapsules Based on Biopolymer Soybean Isolate Proteins: Improving Tannic Acid’s Biocompatibility and Sustained-Release Performance" Molecules 30, no. 11: 2373. https://doi.org/10.3390/molecules30112373

APA Style

Zhang, S., Yan, R., Zhang, S., & Lu, Y. (2025). W/O/W Multiple Emulsified Microcapsules Based on Biopolymer Soybean Isolate Proteins: Improving Tannic Acid’s Biocompatibility and Sustained-Release Performance. Molecules, 30(11), 2373. https://doi.org/10.3390/molecules30112373

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