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Article

Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution

by
Marek Pająk
1,*,
Elżbieta Kamysz
2,
Karol Sikora
3,
Jakub Fichna
4 and
Magdalena Woźniczka
1
1
Department of Physical and Biocoordination Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland
2
Laboratory of Chemistry of Biological Macromolecules, Department of Molecular Biotechnology, Faculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland
3
Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland
4
Department of Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(1), 90; https://doi.org/10.3390/molecules29010090
Submission received: 13 December 2023 / Revised: 18 December 2023 / Accepted: 19 December 2023 / Published: 22 December 2023
(This article belongs to the Special Issue Amino Acid or Peptide Based Metal Complexes)
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Abstract

The present work describes the complexation of the anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature of 25.0 ± 0.1 °C, over the whole pH range. The complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. The potentiometric method was used to calculate the logarithms of the overall stability constants (log β) and the values of the stepwise dissociation constants (pKa) of the studied complexes. The percentage of each species formed in an aqueous solution was estimated from the species distribution curve as a function of pH. The absorbance (A) and molar absorption coefficient (ε) values for the Cu(II)-sialorphin derivative system were determined with UV-Vis spectroscopy. Our studies indicate that the sialorphin derivative forms stable complexes with Cu(II) ions, which may lead to future biological and therapeutic applications.
Keywords: sialorphin; Cu(II) complexes; palmitic acid; potentiometry; UV-Vis spectroscopy; protonation constant; stability constant sialorphin; Cu(II) complexes; palmitic acid; potentiometry; UV-Vis spectroscopy; protonation constant; stability constant

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MDPI and ACS Style

Pająk, M.; Kamysz, E.; Sikora, K.; Fichna, J.; Woźniczka, M. Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution. Molecules 2024, 29, 90. https://doi.org/10.3390/molecules29010090

AMA Style

Pająk M, Kamysz E, Sikora K, Fichna J, Woźniczka M. Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution. Molecules. 2024; 29(1):90. https://doi.org/10.3390/molecules29010090

Chicago/Turabian Style

Pająk, Marek, Elżbieta Kamysz, Karol Sikora, Jakub Fichna, and Magdalena Woźniczka. 2024. "Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution" Molecules 29, no. 1: 90. https://doi.org/10.3390/molecules29010090

APA Style

Pająk, M., Kamysz, E., Sikora, K., Fichna, J., & Woźniczka, M. (2024). Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution. Molecules, 29(1), 90. https://doi.org/10.3390/molecules29010090

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