A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Photophysical Properties of Photosensitizers
2.2. Biological Studies
2.3. Intracellular Localization of PSs in UMUC3 (Bladder) and U87 (Brain) Tumor Cells
2.4. In Vivo Uptake and PDT Efficacy
2.5. Comparative In Vivo PDT Efficacy
3. Conclusions
4. Experimental Section
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
Abbreviations
References
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Compound | λabs, nm | λem, nm | τav, ns | QYF | QYSO |
---|---|---|---|---|---|
2 | 410, 504, 537, 606, 664 | 665, 697 | 6.30 | 0.043 | 0.488 |
3 | 411, 504, 534, 605, 663 | 664, 697 | 6.89 | 0.043 | 0.466 |
4 | 411, 504, 534, 605, 663 | 664, 697 | 8.33 | 0.050 | 0.500 |
5 | 410, 503, 534, 606, 664 | 664, 697 | 6.92 | 0.041 | 0.489 |
6 | 410, 503, 536, 606, 664. | 664, 697 | 6.72 | 0.038 | 0.430 |
7 | 410, 503, 535, 604, 664 | 664, 697 | 6.68 | 0.046 | 0.437 |
8 | 411, 503, 536, 604, 643 | 664, 697 | 6.68 | 0.046 | 0.487 |
PS | IC50 (mM) UMUC3 | IC50 (mM) U87 | PS | IC50 (mM) UMUC3 | IC50 (mM) U87 |
---|---|---|---|---|---|
2 | 0.095 | 0.534 | 6 | 0.009 | 0.202 |
3 | 0.022 | 0.227 | 7 | 0.048 | 0.303 |
4 | 0.014 | 0.145 | 8 | 0.027 | 0.027 |
5 | 0.018 | 0.284 |
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Pandurang, T.P.; Cacaccio, J.; Durrani, F.A.; Dukh, M.; Alsaleh, A.Z.; Sajjad, M.; D’Souza, F.; Kumar, D.; Pandey, R.K. A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity. Molecules 2023, 28, 3782. https://doi.org/10.3390/molecules28093782
Pandurang TP, Cacaccio J, Durrani FA, Dukh M, Alsaleh AZ, Sajjad M, D’Souza F, Kumar D, Pandey RK. A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity. Molecules. 2023; 28(9):3782. https://doi.org/10.3390/molecules28093782
Chicago/Turabian StylePandurang, Taur Prakash, Joseph Cacaccio, Farukh A. Durrani, Mykhaylo Dukh, Ajyal Z. Alsaleh, Munawwar Sajjad, Francis D’Souza, Dalip Kumar, and Ravindra K. Pandey. 2023. "A Remarkable Difference in Pharmacokinetics of Fluorinated Versus Iodinated Photosensitizers Derived from Chlorophyll-a and a Direct Correlation between the Tumor Uptake and Anti-Cancer Activity" Molecules 28, no. 9: 3782. https://doi.org/10.3390/molecules28093782