Chemico-Physical Properties of Some 1,1′-Bis-alkyl-2,2′-hexane-1,6-diyl-bispyridinium Chlorides Hydrogenated and Partially Fluorinated for Gene Delivery
Abstract
:1. Introduction
2. Results and Discussion
2.1. Micelle Formation Thermodynamics
2.2. Biological Assays of GP12_6
2.3. CD Spectroscopy
2.4. Ellipsometry and Surface Pressure
3. Materials and Methods
3.1. Compounds
3.2. Chemical Synthesis
3.3. ITC Measurements
3.4. Biological Assays
3.5. Sample Preparation and AFM Imaging
3.6. Circular Dichroism Spectroscopy
3.7. Surface Tension Measurements
3.8. Ellipsometry
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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cmc [mM] | xcmc 105 | ΔHmic [kJ mol−1] | ΔGmic [kJ mol−1] | ΔSmic [J K−1 mol−1] | |
---|---|---|---|---|---|
FGP6 | 0.89 | 1.603 | −6.1 | −27.4 | 71 |
FGP8 | 0.77 | 1.387 | −6.2 | −27.7 | 72 |
GP12-6 | 0.92 | 1.657 | −6.5 | −27.3 | 70 |
GP16-6 | 0.41 | 0.738 | −14.0 | −29.3 | 51 |
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Massa, M.; Rivara, M.; Pertinhez, T.A.; Compari, C.; Donofrio, G.; Cristofolini, L.; Orsi, D.; Franceschi, V.; Fisicaro, E. Chemico-Physical Properties of Some 1,1′-Bis-alkyl-2,2′-hexane-1,6-diyl-bispyridinium Chlorides Hydrogenated and Partially Fluorinated for Gene Delivery. Molecules 2023, 28, 3585. https://doi.org/10.3390/molecules28083585
Massa M, Rivara M, Pertinhez TA, Compari C, Donofrio G, Cristofolini L, Orsi D, Franceschi V, Fisicaro E. Chemico-Physical Properties of Some 1,1′-Bis-alkyl-2,2′-hexane-1,6-diyl-bispyridinium Chlorides Hydrogenated and Partially Fluorinated for Gene Delivery. Molecules. 2023; 28(8):3585. https://doi.org/10.3390/molecules28083585
Chicago/Turabian StyleMassa, Michele, Mirko Rivara, Thelma A. Pertinhez, Carlotta Compari, Gaetano Donofrio, Luigi Cristofolini, Davide Orsi, Valentina Franceschi, and Emilia Fisicaro. 2023. "Chemico-Physical Properties of Some 1,1′-Bis-alkyl-2,2′-hexane-1,6-diyl-bispyridinium Chlorides Hydrogenated and Partially Fluorinated for Gene Delivery" Molecules 28, no. 8: 3585. https://doi.org/10.3390/molecules28083585