Research Progress of Dihydroquercetin in the Treatment of Skin Diseases
, Dengjun Qiu 1, Tong Yang 1, Jingxu Su 1, Chengyuan Liu 1, Xinyue Su 1, Anning Li 2, Pingping Sun 2, Jianguo Li 2, Li Yan 2, Chuanbo Ding 1,2,* and Shuai Zhang 3,*Round 1
Reviewer 1 Report
In this review, the application of dihydroquercetin in medical dressings and the research progress in the treatment of skin-related diseases are reviewed, so as to provide reference for further developing dihydroquercetin as a drug for the treatment of skin diseases. Authors reported skin diseases and treatment and the dihydroquercetin loaded wound dressing has been reported as a research progress of dihydroquercetin. It is a good effort.
1. In table no.1 and column 2” common classification of skin????” incomplete heading please check and correct
2. In Line 223, I. Batubara; “I” must be removed. Please check the manuscript thoroughly for grammatical errors
3. Please check and fix the plagiarism again.
4. Diagrams like general mechanisms of action of dihydroquercetin or antioxidant, anti-viral and anti-inflammatory effect can be added to improve the quality of the manuscript and for better understanding of the underlying mechanism.
5. Conclusion must be more precise with a crisp to grab the reader attention
6. Also check references carefully
7. A general mechanism of action of dihydroquercetin as “anti-inflammatory, antimicrobial or antioxidant agent”, in the form of a figure or schematic diagram must be added in the review so that a reader can get maximum information by reading this manuscript.
8. A table on “dihydroquercetin loaded wound dressing technique/materials” can be added in this review. Many research articles have been published related to wound dressing techniques/materials topic. Few references are as follows
Shevelev AB, La Porta N, Isakova EP, Martens S, Biryukova YK, Belous AS, Sivokhin DA, Trubnikova EV, Zylkova MV, Belyakova AV, Smirnova MS. In vivo antimicrobial and wound-healing activity of resveratrol, dihydroquercetin, and dihydromyricetin against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Pathogens. 2020 Apr 17;9(4):296.
Terekhov RP, Selivanova IA, Anurova MN, Zhevlakova AK, Nikitin ID, Cong Z, Ma S, Yang F, Dong Z, Liao Y. Comparative study of wound-healing activity of dihydroquercetin pseudopolymorphic modifications. Bulletin of Experimental Biology and Medicine. 2021 Feb; 170:444-7.
Sajadi-Javan ZS, Varshosaz J, Mirian M, Manshaei M, Aminzadeh A. Thermo-responsive hydrogels based on methylcellulose/Persian gum loaded with taxifolin enhance bone regeneration: An in vitro/in vivo study. Cellulose. 2022 Mar;29(4):2413-33.
Quality of english is good but it can be improved significantly
Author Response
Response to Reviewer 1 Comments
Dear reviewer:
First of all, thank you very much for your comments on the manuscript (2607194), and these suggestions are very helpful to improve our manuscript. We have taken these suggestions and revised the manuscript according to the comments. The comments raised by the referees are answered and explained as follows:
Reviewer #1: In this review, the application of dihydroquercetin in medical dressings and the research progress in the treatment of skin-related diseases are reviewed, so as to provide reference for further developing dihydroquercetin as a drug for the treatment of skin diseases. Authors reported skin diseases and treatment and the dihydroquercetin loaded wound dressing has been reported as a research progress of dihydroquercetin. It is a good effort.
- In table no.1 and column 2” common classification of skin????” incomplete heading please check and correct.
Response： Thanks for your comments. We have modified Table 1 and marked the modified parts in red font.
- In Line 223, I. Batubara; “I” must be removed. Please check the manuscript thoroughly for grammatical errors.
Response： Thanks for your comments. We have made revisions and checked the article for grammatical issues.
- Please check and fix the plagiarism again.
Response： Thanks for your comments. We have made adjustments to the citations section and reduced the duplication rate of articles.
- Diagrams like general mechanisms of action of dihydroquercetin or antioxidant, anti-viral and anti-inflammatory effect can be added to improve the quality of the manuscript and for better understanding of the underlying mechanism.
Response： Thanks for your comments. We have added a table of the mechanism of action of dihydroquercetin to the article and marked it in red font.
- Conclusion must be more precise with a crisp to grab the reader attention
Response： Thanks for your comments. We have revised the conclusion and marked it in red font.
- Also check references carefully.
Response： Thanks for your comments. We checked and revised the format of the references. We have marked the modified parts in red font.
- A general mechanism of action of dihydroquercetin as “anti-inflammatory, antimicrobial or antioxidant agent”, in the form of a figure or schematic diagram must be added in the review so that a reader can get maximum information by reading this manuscript.
Response： Thanks for your comments. We have included a diagram of the mechanism of action of dihydroquercetin in the manuscript.
- A table on “dihydroquercetin loaded wound dressing technique/materials” can be added in this review. Many research articles have been published related to wound dressing techniques/materials topic. Few references are as follows
Shevelev AB, La Porta N, Isakova EP, Martens S, Biryukova YK, Belous AS, Sivokhin DA, Trubnikova EV, Zylkova MV, Belyakova AV, Smirnova MS. In vivo antimicrobial and wound-healing activity of resveratrol, dihydroquercetin, and dihydromyricetin against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Pathogens. 2020 Apr 17;9(4):296.
Terekhov RP, Selivanova IA, Anurova MN, Zhevlakova AK, Nikitin ID, Cong Z, Ma S, Yang F, Dong Z, Liao Y. Comparative study of wound-healing activity of dihydroquercetin pseudopolymorphic modifications. Bulletin of Experimental Biology and Medicine. 2021 Feb; 170:444-7.
Sajadi-Javan ZS, Varshosaz J, Mirian M, Manshaei M, Aminzadeh A. Thermo-responsive hydrogels based on methylcellulose/Persian gum loaded with taxifolin enhance bone regeneration: An in vitro/in vivo study. Cellulose. 2022 Mar;29(4):2413-33.
Response： Thanks for your comments. We have added a table of dihydroquercetin loaded wound dressings and referenced the provided article.
Author Response File: 
Author Response.docx
Reviewer 2 Report
Dear author
Is an interesting review, and I just have some comments:
Please check editing errors in your manuscript
Maybe creating an image of the mechanisms would be very illustrative for your review.
Line 20. Improve keywords
Line 25. Check reference format
Line 38-40. Edit this part please
Line 46: change Onions by onions
Line 46-50: Edit paragraph please, you repeat “skin” word needlessly
Line 55-58: Edit paragraph
Line 59: In table 1. “Common classification of the skin” does not apply, it is rather a disease, and “Represents disease” are syntoms? . Is not clear, check please.
Line 273-289. This paragraph needs to be edit, because pycogenol is a mixture of antioxidant compounds, not necessarily just dihydroquercetin.
Line- 278: “vitamins e and C”, check please
Figure 1. Improve image as well as title of figure
Line 296: qiteng? Is part of the reference? Check, please
Line 309-310: Check, scientific name format
“Staphylococcus aureus and Escherichia coli”
Line 298-320: Abbreviations of chitosan must be the same in your text
Line 363: In reference part you have this mistake, check please
https://doi.org/https://doi.org/10.1016/j.colsurfb.2023.113197.
Regards
Author Response
Please see the attachment
Author Response File: Author Response.docx
Reviewer 3 Report
The review presents a synthesis on dihydroquercetin applications and results in the treatment of skin diseases.
I consider that it does not fit in the journal topic or, at least, not meeting its standards. Actually, more than half part of the article is presenting a summary of the skin diseases, based on a relevant bibliographic research (52 references from 76 of the entire bibliography). In rest, mechanisms in which dihydroquercetin acts in skin diseases treatment are presented in a too simplistic way.
Given the above observations, I consider that the article should be submitted to a journal whose aim is focused on skin diseases.
Besides these, please revise the text editing:
line 38 – the sentence should be reformulated “Dihydroquercetin, also known as Taxifolin, is a unique ……”
lines 118 and 214 – capital letters for paragraph titles
Author Response
Please see the attachment
Author Response File: Author Response.docx
Round 2
Reviewer 3 Report
Accept in its present form
Author Response
Dear reviewer:
First of all, thank you very much for your comments on the manuscript (2607194), and these suggestions are very helpful to improve our manuscript. We have taken these suggestions and revised the manuscript according to the comments. The comments raised by the referees are answered and explained as follows:
Reviewer #3: Accept in its present form.
Response： Thank you for your recognition. If you have any other questions, we will respond actively.
