Research Progress of Dihydroquercetin in the Treatment of Skin Diseases
Abstract
:1. Introduction
2. Classification of Skin Diseases
2.1. Skin Cancer
2.2. Atopic Dermatitis
2.3. Psoriasis
2.4. Skin Acne
2.5. Chloasma
3. Skin Dressing
4. Application of Dihydroquercetin in the Treatment of Skin Diseases
4.1. Treatment of Skin Cancer
4.2. Treatment of Psoriasis
4.3. Treatment of Skin Inflammation
4.4. Delay Skin Aging
4.5. Treatment of Skin Acne
4.6. Dihydroquercetin Promotes Wound Healing
4.7. Dihydroquercetin Treatment of Skin Burns
4.8. Treatment of Skin Ulcer and Chloasma
5. Dihydroquercetin Loaded Wound Dressing
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Serial Number | Skin Diseases | Represents Disease | References |
---|---|---|---|
1 | Skin cancer | Basal cell carcinoma of the skin, squamous cell carcinoma, malignant melanoma, nodule | [7,8,9] |
2 | Inflammatory dermatosis | Psoriasis, atopic dermatitis, autoimmune vesicular disease, and alopecia areata | [10,11] |
3 | Erythematopapular scaling dermatosis | Psoriasis, subcorneal pustular skin disease, pityriasis rosea, seborrheic dermatitis, and nummular dermatitis | [12] |
4 | Skin and accessory organ diseases | Acne, rosacea, skin ulcers, etc | [13,14,15] |
5 | Pigment disorder is a skin disease | Chloasma, vitiligo, pigmented nevus, freckle nevus, etc. | [16,17,18,19] |
6 | Viral skin diseases | Herpes simplex, herpes zoster, warts, molluscum contagiosum, hand, foot, and mouth disease | [20] |
7 | Bacterial dermatosis | Impetigo, folliculitis, erysipelas, and leprosy | [21,22] |
8 | Fungal dermatosis | Tinea corporis, tinea pedis, onychomycosis, pityriasis versicolor, malassezia folliculitis, etc | [23] |
9 | sexually transmitted disease | Syphilis, gonorrhea, and condyloma acuminatum | [24,25] |
10 | allergic skin diseases | Contact dermatitis, eczema, urticaria, drug reaction | [26,27] |
11 | Neurofunctional dermatosis | Prurigo nodosa, neurodermatitis, and parasitic paranoia | [28,29] |
12 | Connective tissue diseases | Lupus erythematosus, scleroderma, and dermatomyositis | [30] |
13 | Bullous skin diseases | Pemphigus, bullous pemphigoid, cicatricial pemphigoid, herpetic dermatitis, linear IgA bullous dermatosis, acquired epidermolysis bullosa, pemphigoid pregnancy | [31] |
14 | Genodermatoses | Ichthyosis vulgaris, keratosis folliculi, albinism, hirsutism, epidermolysis bullosa, tinea versicolor | [32,33] |
15 | Nutrition and disordered metabolic dermatosis | Vitamin deficiency | [34,35] |
Biological Activity | Experimental Model | Mechanism |
---|---|---|
Anti-inflammatory | C57BL/6 mice | Regulating the TLR4/NF-κB axis to prevent inflammation and apoptosis. |
RAW 264.7 cells | Regulates the expression of iNOS, VEGF, COX-2, and TNF-α and affects the MAPK signaling pathway. | |
SD rat | Inhibition of microglial pyroptosis via the PI3K/Akt signaling pathway | |
DMM rats and chondrocytes | Activating the Nrf2 pathway inhibits inflammation, alleviates apoptosis, and reduces ECM degradation to reshape the articular cartilage microenvironment. | |
BV2 cell line | Upregulates pAMPK levels and activates the Nrf2/HO-1 signaling pathway | |
Antibacterial | E. coli and Staphylococcus aureus | Destroy the integrity of bacterial cell walls and membranes, inhibit bacterial biofilm formation, cause stress, and lead to increased superoxide dismutase and alkaline phosphatase activities in bacteria |
Antioxidants | Westal rat | Reduce oxidative stress and reduce pro-inflammatory cytokine levels |
glutamatergic neurons | Inhibition of basal and OGD-induced mitochondrial ROS production in GABAergic neurons. | |
Antiviral | HAV stock: CF 53 | Reduce the infectivity and antigenicity of HAV |
Dressing Type | Experimental Model | Mechanism |
---|---|---|
Nanofiber membrane | Diabetic mice | It Inhibits the activation of κBα (IκBα)/nuclear factor κB (NF-κB) signaling pathway and increases the expression of CD and VEGF in skin tissue |
Human skin keratinocytes | Prevent oxidative stress, inflammation, and apoptosis induced by UVA radiation-induced MAPK/Nrf2 signaling pathway | |
Mice | The PI3K/AKT/MR signaling pathway is significantly inhibited to activate autophagy and promote skin repair. | |
Female Wistar rats | Good antioxidant, antibacterial, and anti-inflammatory activity. |
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Liu, Z.; Qiu, D.; Yang, T.; Su, J.; Liu, C.; Su, X.; Li, A.; Sun, P.; Li, J.; Yan, L.; et al. Research Progress of Dihydroquercetin in the Treatment of Skin Diseases. Molecules 2023, 28, 6989. https://doi.org/10.3390/molecules28196989
Liu Z, Qiu D, Yang T, Su J, Liu C, Su X, Li A, Sun P, Li J, Yan L, et al. Research Progress of Dihydroquercetin in the Treatment of Skin Diseases. Molecules. 2023; 28(19):6989. https://doi.org/10.3390/molecules28196989
Chicago/Turabian StyleLiu, Ziyang, Dengjun Qiu, Tong Yang, Jingxu Su, Chengyuan Liu, Xinyue Su, Anning Li, Pingping Sun, Jianguo Li, Li Yan, and et al. 2023. "Research Progress of Dihydroquercetin in the Treatment of Skin Diseases" Molecules 28, no. 19: 6989. https://doi.org/10.3390/molecules28196989