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Article

Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities

by
Elaine-Jinfeng Chin
†,
Kuan-Chieh Ching
†,
Zann Y. Tan
,
Mario Wibowo
,
Chung-Yan Leong
,
Lay-Kien Yang
,
Veronica W. P. Ng
,
Deborah C. S. Seow
,
Yoganathan Kanagasundaram
* and
Siew-Bee Ng
*
Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2023, 28(15), 5832; https://doi.org/10.3390/molecules28155832
Submission received: 28 June 2023 / Revised: 26 July 2023 / Accepted: 26 July 2023 / Published: 2 August 2023
(This article belongs to the Special Issue Natural Products as Antimicrobial Agents: From Extraction to Therapeutic Applications)
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Abstract

Natural products have long been used as a source of antimicrobial agents against various microorganisms. Actinobacteria are a group of bacteria best known to produce a wide variety of bioactive secondary metabolites, including many antimicrobial agents. In this study, four actinobacterial strains found in Singapore terrestrial soil were investigated as potential sources of new antimicrobial compounds. Large-scale cultivation, chemical, and biological investigation led to the isolation of a previously undescribed tetronomycin A (1) that demonstrated inhibitory activities against both Gram-positive bacteria Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA) (i.e., MIC90 of 2–4 μM and MBC90 of 9–12 μM), and several known antimicrobial compounds, namely nonactin, monactin, dinactin, 4E-deacetylchromomycin A3, chromomycin A2, soyasaponin II, lysolipin I, tetronomycin, and naphthomevalin. Tetronomycin showed a two- to six-fold increase in antibacterial activity (i.e., MIC90 and MBC90 of 1–2 μM) as compared to tetronomycin A (1), indicating the presence of an oxy-methyl group at the C-27 position is important for antibacterial activity.
Keywords: actinobacteria; antimicrobial; Staphylococcus aureus; Streptomycetaceae; tetronomycin; natural products actinobacteria; antimicrobial; Staphylococcus aureus; Streptomycetaceae; tetronomycin; natural products

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MDPI and ACS Style

Chin, E.-J.; Ching, K.-C.; Tan, Z.Y.; Wibowo, M.; Leong, C.-Y.; Yang, L.-K.; Ng, V.W.P.; Seow, D.C.S.; Kanagasundaram, Y.; Ng, S.-B. Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities. Molecules 2023, 28, 5832. https://doi.org/10.3390/molecules28155832

AMA Style

Chin E-J, Ching K-C, Tan ZY, Wibowo M, Leong C-Y, Yang L-K, Ng VWP, Seow DCS, Kanagasundaram Y, Ng S-B. Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities. Molecules. 2023; 28(15):5832. https://doi.org/10.3390/molecules28155832

Chicago/Turabian Style

Chin, Elaine-Jinfeng, Kuan-Chieh Ching, Zann Y. Tan, Mario Wibowo, Chung-Yan Leong, Lay-Kien Yang, Veronica W. P. Ng, Deborah C. S. Seow, Yoganathan Kanagasundaram, and Siew-Bee Ng. 2023. "Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities" Molecules 28, no. 15: 5832. https://doi.org/10.3390/molecules28155832

APA Style

Chin, E.-J., Ching, K.-C., Tan, Z. Y., Wibowo, M., Leong, C.-Y., Yang, L.-K., Ng, V. W. P., Seow, D. C. S., Kanagasundaram, Y., & Ng, S.-B. (2023). Natural Products from Singapore Soil-Derived Streptomycetaceae Family and Evaluation of Their Biological Activities. Molecules, 28(15), 5832. https://doi.org/10.3390/molecules28155832

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